PTSD, Trauma Patients
Conditions
Brief summary
The goal of this observational study is to learn about the long-term effects of key factors such as cognitive flexibility, social support, and physiological stress on the occurrence of Post-Traumatic Stress Disorder (PTSD) in adult trauma patients treated in the emergency department. The main question it aims to answer is: Among emergency department patients who have experienced major trauma, can factors such as early post-trauma cognitive flexibility, level of social support, inflammatory markers, and trauma severity predict the development of PTSD within 6 months? Participants will complete a series of online questionnaires and clinical assessments at baseline, 1 month, 3 months, and 6 months after the traumatic event.
Interventions
None listed
Sponsors
The First Affiliated Hospital of Air Force Medicial University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Age between 18 and 65 years old (inclusive); * Experienced a life-threatening major traumatic event, clearly diagnosed by a clinician; * The patient is able to communicate normally with medical staff through language; * The subject is fully informed and voluntarily signs the informed consent form.
Exclusion criteria
* History of psychiatric disorders or current use of psychotropic medications; * Pre-existing cognitive impairment (e.g., dementia, Alzheimer's disease); * Terminal illnesses (such as advanced malignant tumors, end-stage organ failure, advanced neurological diseases, or any other condition judged by the attending physician to have a life expectancy of less than 6 months); * Inability to cooperate with follow-up.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| PTSD Incidence as Assessed by the PTSD Checklist for DSM-5 (PCL-5) | 6 months post-trauma | Number of participants with a total score ≥33 on the PCL-5 (range 0-80, higher scores indicate more severe PTSD symptoms) at 6 months after the traumatic event, indicating probable post-traumatic stress disorder (PTSD). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Association of Sociodemographic, Trauma-Related, and Psychosocial Factors with PTSD Status | Baselin and 6 months post-trauma | Odds ratios (ORs) and 95% confidence intervals for the association of each candidate factor (e.g., age, sex, injury severity score \[ISS\], social support \[SSRS score\], anxiety/depression \[HADS score\], cognitive flexibility \[CFI score\], inflammatory biomarkers \[IL-6, CRP\]) with probable PTSD status at 6 months, as determined by multivariable logistic regression. |
Contacts
CONTACTyang li, Master's Student
Outcome results
None listed