A Longitudinal Cohort Study on the Changes of Physiological Mechanisms in Children After Biliary Tract Reconstruction

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07530354

Enrollment

100

Registered

2026-04-15

Start date

2025-05-01

Completion date

2035-04-30

Last updated

2026-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Choledochal Cyst

Keywords

Choledochal Cyst, Cholecystectomy, Cohort Studies, Treatment Outcome, Surgical Procedures

Brief summary

Through observational studies, the long-term changes in liver function, metabolic state, immune response and other aspects of children after biliary tract reconstruction during their growth process were systematically explored. The risks of these long-term physiological changes on chronic diseases such as cardiovascular diseases, diabetic diseases and liver cirrhosis in adulthood, as well as their impacts on cognitive function, musculoskeletal health and other aspects were evaluated. How do early physiological changes affect a patient's long-term health? Are there any potential biomarkers that can predict future health outcomes? Based on the research results, preventive and intervention measures that are helpful in reducing the risk of long-term complications are proposed.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

No minimum to 16 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy children matched by age and gender were selected as the control group

Exclusion criteria

* Combined with other serious diseases (such as cancer, autoimmune diseases), having obvious liver function abnormalities before surgery or being undergoing other major treatments.

Design outcomes

Primary

Measure	Time frame	Description
Targeted metabolic component detection of feces	Baseline (pre-operative); 1 week, 1 month, 3 months, 6 months, 1 year, 2 years, 3 years post-operative	Metabolite concentration in feces measured by targeted metabolomics
Detection of targeted metabolic components in plasma	Baseline (pre-operative); 1 week, 1 month, 3 months, 6 months, 1 year, 2 years, 3 years post-operative	Metabolite concentration in plasma measured by targeted metabolomics

Secondary

Measure	Time frame	Description
Fecal metagenomic sequencing	Baseline (pre-operative); 1 week, 1 month, 3 months, 6 months, 1 year, 2 years, 3 years post-operative	Gut microbial composition and functional genes assessed by fecal metagenomic sequencing

Countries

China

Contacts

CONTACTXueqiang Yan

yanxueqiang1@163.com+8615871716704

CONTACTJing Zhang

zhanjing010308@163.com+8613396086020

Outcome results