Fibromuscular Dysplasia, Fibromuscular Dysplasia of Arteries, Spontaneous Coronary Artery Dissection
Conditions
Keywords
FMD, Fibromuscular dysplasia, SCAD, Exercise, Quality of life
Brief summary
Fibromuscular dysplasia (FMD) is a disease of the arteries that is not due to plaque build-up or inflammation. While some patients with FMD are health, some may experience heart attacks, strokes, aneurysms or blood vessel dissection/tearing which can be life-threatening. It predominantly impacts women and younger patients. As a result of this diagnosis, many patients are counseled to restrict or avoid certain physical activities out of concern for provoking or worsening vascular complications. There are no guidelines or consensus recommendations regarding appropriate physical activity for patients with FMD. The lack of consensus may lead to confusion for patients and may negatively impact their quality of life. This study will conduct a large, national survey of patients with FMD to assess the type of physical activity restrictions and impact on quality of life and emotional well-being.
Detailed description
Fibromuscular dysplasia (FMD) is a non-atherosclerotic, non-inflammatory disease of medium-sized arteries characterized by intimal and medial hyperplasia. The exact prevalence of FMD is unknown, but it predominantly impacts women and middle-age patients, with a mean age of 52 at the time of diagnosis. The manifestations of FMD are variable and may include spontaneous coronary artery dissection (SCAD) as well as extra-coronary vascular abnormalities (EVAs), such as peripheral artery aneurysms or dissections. Many patients are counseled to restrict or avoid certain physical activities out of concern for provoking or worsening vascular complications.3,4 However, there are no guidelines or consensus recommendations regarding appropriate physical activity for patients with FMD in the available 2018 American Heart Association (AHA) Scientific statement or the 2019 first international consensus document on FMD. Recommendations are formed based on expert opinion, and may vary based on a variety of factors including severity of disease, treating institution, or sex. The lack of consensus may lead to confusion for patients and may negatively impact their quality of life. This survey will be delivered electronically via RedCap to participants who self-identify as having a diagnosis of fibromuscular dysplasia. It will be the first to identify the breadth and content, as well as the impact, of physical activity recommendations provided by healthcare personnel to patients with FMD. Data gathered from this study will encourage the creation of an expert consensus document on recommendations for physical activity by FMD phenotype, which will have implications for patient education and empowerment for those living with FMD. This may also lead to areas of future intervention to mitigate adverse quality of life if identified.
Interventions
None listed
Sponsors
Vanderbilt University Medical Center
Fibromuscular Dysplasia Society of America
Study design
Observational model
OTHER
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 100 Years
Healthy volunteers
No
Inclusion criteria
* Participants with a diagnosis of fibromuscular dysplasia * Age range = 18-100 years
Exclusion criteria
* Subjects who have an inability to complete the electronic consent form or electronic survey for any reason * Subjects who are non-English speaking who cannot read the electronic consent form or electronic survey
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Clinician-Recommended Physical Activity Restrictions | Baseline | Prevalence and type of clinician-recommended physical activity restrictions among patients diagnosed with fibromuscular dysplasia (FMD), including aerobic, resistance, and activity-specific limitations. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Self-Reported Change in Physical Activity Following Diagnosis | Baseline | Change in physical activity behavior following FMD diagnosis based on patient self-report. |
| Emotional Impact of Physical Activity Recommendations | Baseline | Self-reported anxiety or depression to physical activity recommendations and/or disease-related limitations. |
| Physical Impact of Activity Recommendations | Baseline | Self-reported physical consequences (e.g. weight gain, sedentary lifestyle) associated with modification of activity level following FMD diagnosis. |
Countries
United States
Contacts
CONTACTAmanda Morrison, MD
STUDY_CHAIRAaron W Aday, MD, MSc
Vanderbilt University Medical Center
Outcome results
None listed