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Emergency Department-Substance Use Screening, Motivational Interviewing and Active Referral Targeting Substance Use Disorder and Overdose Prevention

ED-SMART: Emergency Department-Substance Use Screening, Motivational Interviewing and Active Referral Targeting Substance Use Disorder and Overdose Prevention

Status
Enrolling by invitation
Phases
Unknown
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07527871
Acronym
ED-SMART
Enrollment
650
Registered
2026-04-14
Start date
2026-06-17
Completion date
2029-09-01
Last updated
2026-07-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Substance Use (Drugs, Alcohol)

Keywords

substance use

Brief summary

The purpose of this research study is to learn if an emergency department screening and telehealth intervention reduces substance use among individuals receiving emergency department treatment at The Ohio State University Wexner Medical Center.

Interventions

BEHAVIORALED-SMART intervention

The ED-SMART intervention will include: (i) a brief (approximately 15 minutes) counseling session in the emergency department and (ii) five, monthly brief counseling sessions (approximately 15 to 30 minutes) delivered by telehealth. These sessions will focus on creating individualized strategies to help participants reach their alcohol and substance use reduction goals

BEHAVIORALSubstance use information

The substance use information condition will receive printed health information covering information about substance use (e.g., definitions, hazards, potential for addiction, injury, and other consequences). Research staff will also discuss ways to utilize primary care or establish care with a primary care provider to provide ongoing follow-up.

Sponsors

Purdue University
Lead SponsorOTHER
Centers for Disease Control and Prevention
CollaboratorFED

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Adult at least 18 years of age * Capacity and willingness to participate (including reliable phone or internet access for counseling session) * Lower or Moderate Risk score on one or more substance use types on National Institute on Drug Abuse (NIDA)-Modified Alcohol, Smoking, and Substance Use Involvement Test (ASSIST). Participants may also endorse alcohol use in conjunction with substance use as indicated by an Alcohol Use Disorder Identification Test-Concise (AUDIT-C) score of Moderate Risk.

Exclusion criteria

* A priori participant request for participation * Previously enrolled in this or other study of substance use disorder prevention * Language other than English * Expected/actual ED disposition of hospitalization or non-independent status * Prisoner at time of enrollment * Known to be pregnant at time of enrollment * Past substance use disorder or substance use treatment * High risk score for one or more substances on the NIDA-Modified ASSIST or problematic alcohol use alone

Design outcomes

Primary

MeasureTime frameDescription
Self-reported substance useFrom baseline to the sixth month follow-up assessmentSelf-reported substance use frequency

Secondary

MeasureTime frameDescription
Self-reported substance use quantityFrom baseline to the six month follow-upSelf-reported substance use quantity for each substance
Incidence of positive substance use disorder screenFrom baseline to the six month follow-upIncidence of positive substance use disorder screen as measured by the NIDA Modified ASSIST or AUDIT
Toxicology assays for substance useFrom baseline to the six month follow-up assessmentProportion with positive toxicology assay for substance use
Self-reported healthcare utilizationBaseline to the six month follow-up assessmentSelf-reported healthcare utilization
Fatal and non-fatal overdoseBaseline to the six month follow-up assessmentFrequency of fatal and non-fatal overdose

Countries

United States

Contacts

PRINCIPAL_INVESTIGATORJennifer L. Brown, PhD

Purdue University

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Jul 24, 2026