Periodontitis, Aggressive
Conditions
Keywords
Inflammation, Periodontal Debridement, Periodontitis, Systemic Biomarkers
Brief summary
The goal of this clinical study was to evaluate whether non-surgical treatment for severe periodontitis (gum disease) could improve body-wide inflammation and blood fat levels in young adults with severe periodontitis. The main questions it aimed to answer were: Did non-surgical periodontal treatment improve gum health in young adults with severe periodontitis? Did non-surgical periodontal treatment change body-wide inflammation and blood fat levels after treatment? Researchers compared participants with severe periodontitis to healthy participants without periodontitis. Participants with severe periodontitis: * Received oral hygiene instructions, deep cleaning below the gumline, root surface cleaning, and removal of teeth that could not be saved * Had full-mouth gum examinations * Provided blood samples at the start of the study and again at 2 and 6 months after treatment Healthy participants: * Had gum examinations * Provided blood samples for comparison at the start of the study
Interventions
PROCEDURENon-surgical periodontal treatment
Non-surgical periodontal treatment consisted of oral hygiene instruction, subgingival scaling, root planing, and extraction of unsalvageable teeth under local anesthesia. Treatment was completed within 1 week. Clinical periodontal measurements and blood samples were obtained at baseline and repeated at 2 and 6 months after completion of treatment.
Sponsors
Istanbul University
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
19 Years to 36 Years
Healthy volunteers
Yes
Inclusion criteria
* Young adults aged 19 to 36 years * At least 20 teeth present * Clinical attachment loss of at least 5 mm affecting at least 8 teeth * Bone loss around at least 3 teeth other than incisors and first molars
Exclusion criteria
* Systemic disease * Pregnancy or lactation * Current or former smoking * Systemic conditions that could alter the host response * Medical conditions requiring antibiotic prophylaxis during routine dental procedures * Antibiotic therapy within the previous 6 months * Previous periodontal treatment
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The change in serum high-sensitivity C-reactive protein (hs-CRP) concentration after periodontal treatment | 6 months | This change is measured in serum, as mg/dl, recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. The study was powered on the change in this parameter from baseline to 6 months after treatment. |
| The change in HDL cholesterol concentration after periodontal treatment | 6 months | This parameter is measured in blood samples, as mg/dL, recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the systemic biomarker panel examined to characterize the systemic inflammatory and metabolic profile of the study participants. |
| The change in LDL cholesterol concentration after periodontal treatment | 6 months | This parameter is measured in blood samples, as mg/dL, recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the systemic biomarker panel examined to characterize the systemic inflammatory and metabolic profile of the study participants. |
| The change in total cholesterol concentration after periodontal treatment | 6 months | This parameter is measured in blood samples, as mg/dL, recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the systemic biomarker panel examined to characterize the systemic inflammatory and metabolic profile of the study participants. |
| The change in triglyceride concentration after periodontal treatment | 6 months | This parameter is measured in blood samples, as mg/dL, recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the systemic biomarker panel examined to characterize the systemic inflammatory and metabolic profile of the study participants. |
| The change in albumin concentration after periodontal treatment | 6 months | This parameter is measured in blood samples, as mg/dL, recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the systemic biomarker panel examined to characterize the systemic inflammatory and metabolic profile of the study participants. |
| The change in von Willebrand factor (vWf) level after periodontal treatment | 6 months | This parameter is measured in blood samples, as percentage (%), recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the systemic biomarker panel examined to characterize the systemic inflammatory and metabolic profile of the study participants. |
| The change in creatinine concentration after periodontal treatment | 6 months | This parameter is measured in blood samples, as mg/dL, recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the systemic biomarker panel examined to characterize the systemic inflammatory and metabolic profile of the study participants. |
| The change in fibrinogen concentration after periodontal treatment | 6 months | This parameter is measured in blood samples, as mg/dL, recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the systemic biomarker panel examined to characterize the systemic inflammatory and metabolic profile of the study participants. |
| The change in Factor VII level after periodontal treatment | 6 months | This parameter is measured in blood samples, as percentage (%), recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the systemic biomarker panel examined to characterize the systemic inflammatory and metabolic profile of the study participants. |
| The change in interleukin-1 receptor (IL-1ra) antagonist concentration after periodontal treatment | 6 months | This parameter is measured in blood samples, as pg/mL, recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the systemic biomarker panel examined to characterize the systemic inflammatory and metabolic profile of the study participants. |
| The change in interleukin-6 (IL-6) level after periodontal treatment | 6 months | This parameter is measured in blood samples, as pg/mL, recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the systemic biomarker panel examined to characterize the systemic inflammatory and metabolic profile of the study participants. |
| The change in soluble tumor necrosis factor receptor I (sTNFRI) concentration after periodontal treatment | 6 months | This parameter is measured in blood samples, as pg/mL, recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the systemic biomarker panel examined to characterize the systemic inflammatory and metabolic profile of the study participants. |
| The change in soluble tumor necrosis factor receptor II concentration (sTNFRII) after periodontal treatment | 6 months | This parameter is measured in blood samples, as pg/mL, recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the systemic biomarker panel examined to characterize the systemic inflammatory and metabolic profile of the study participants. |
| The change in tissue plasminogen activator (tPA) concentration after periodontal treatment | 6 months | This parameter is measured in blood samples, as ng/mL, recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the systemic biomarker panel examined to characterize the systemic inflammatory and metabolic profile of the study participants. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The change in sulcus bleeding index (SBI) after periodontal treatment | 6 months | This parameter is measured by clinical examination, as a percentage (%), recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the clinical periodontal parameters recorded to characterize the periodontal status of the study participants. |
| The change in plaque index (PI) after periodontal treatment | 6 months | This parameter is measured by clinical examination, as a percentage (%), recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the clinical periodontal parameters recorded to characterize the periodontal status of the study participants. |
| The change in clinical attachment level (CAL) after periodontal treatment | 6 months | This parameter is measured by clinical examination, in millimeters (mm), recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the clinical periodontal parameters recorded to characterize the periodontal status of the study participants. |
| The change in probing pocket depth (PPD) after periodontal treatment | 6 months | This parameter is measured by clinical examination, in millimeters (mm), recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the clinical periodontal parameters recorded to characterize the periodontal status of the study participants. |
| The change in level of gingival margin (LGM) after periodontal treatment | 6 months | This parameter is measured by clinical examination, in millimeters (mm), recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the clinical periodontal parameters recorded to characterize the periodontal status of the study participants. |
Countries
Turkey (Türkiye)
Outcome results
None listed