Video-EEG Semiological Patterns in PNES

Distinct Semiological Clusters of Psychogenic Non-Epileptic Seizures Identified by Video-EEG Monitoring

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07526467

Enrollment

Registered

2026-04-13

Start date

2025-09-01

Completion date

2026-04-01

Last updated

2026-04-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pnes

Brief summary

This retrospective observational study evaluates semiological and electroclinical characteristics of psychogenic nonepileptic seizures (PNES) in adult patients who underwent video-EEG monitoring. The study aims to identify distinct semiological patterns and classify PNES events based on observable ictal features recorded during video-EEG monitoring.

Detailed description

Psychogenic nonepileptic seizures (PNES) are paroxysmal events that resemble epileptic seizures but are not associated with ictal epileptiform activity on electroencephalography (EEG). Video-EEG monitoring is the gold standard for diagnosis. In this retrospective observational study, video-EEG recordings and clinical data of 52 adult patients diagnosed with PNES were reviewed. Semiological features observed during recorded events were systematically evaluated and coded as binary variables. Hierarchical cluster analysis (Ward's method with squared Euclidean distance) was used to identify semiological patterns. The aim was to define clinically meaningful clusters of PNES events and to describe their demographic and clinical correlates.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

Adults aged 18 years and older Diagnosis of psychogenic nonepileptic seizures (PNES) confirmed by video-EEG monitoring Availability of complete video-EEG recordings capturing at least one typical event Availability of sufficient clinical and demographic data in medical records for retrospective evaluation

Exclusion criteria

Patients younger than 18 years Incomplete or poor-quality video-EEG recordings Absence of recorded typical PNES events during video-EEG monitoring Insufficient clinical documentation for retrospective analysis

Design outcomes

Primary

Measure	Time frame	Description
Semiological cluster classification of PNES events	Baseline (retrospective video-EEG analysis)	Classification of PNES events into semiological clusters (pauci-kinetic, hyperkinetic, hyperventilation-eye closure) based on ictal features identified during video-EEG monitoring.

Secondary

Measure	Time frame	Description
pnes events	baseline	Eye closure during PNES events Hyperventilation during PNES events Abrupt onset of PNES events Abrupt termination of PNES events Hyperkinetic motor activity Presence or absence of excessive motor activity (e.g., thrashing movements). Tremor during PNES events Dystonic posturing Axial extension Axial immobility Pelvic thrusting Presence or absence of pelvic thrusting.

Countries

Turkey (Türkiye)

Contacts

PRINCIPAL_INVESTIGATORirem fatma uludag

Tepecik EAH

Outcome results