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Stepwise PEEP vs Sustained Inflation in Bariatric Surgery Patients

Comparison of Stepwise PEEP vs Sustained Inflation Recruitment Maneuvers on Postoperative Oxygenation and Atelectasis in Bariatric Surgery Patients

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07525232
Enrollment
100
Registered
2026-04-13
Start date
2026-03-19
Completion date
2026-11-01
Last updated
2026-04-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bariatric Surgery Candidate, Recruitment

Brief summary

Male and female patients Undergoing laparoscopic bariatric surgeries will be subjected for lung recruitment at end of surgery before emergence from anesthesia by two different methods . to evaluate which might be safer and more effective

Detailed description

In the SI group:, the anesthesiologist adjust the ventilator to manual ventilation mode and ad¬just The ventilator will be switched to manual mode, and the airway pressure-limiting valve will be set to 30 cmH₂O. A sustained manual inflation was then applied by gradually squeezing the anesthesia reservoir bag over 3-5 seconds until a peak airway pressure (Ppeak) of 30 cmH₂O was achieved. This pressure was maintained continuously for 30 seconds. Following the maneuver, mechanical ventilation was resumed with positive end-expiratory pressure (PEEP) back to 5 cmho In the IP group:, alveolar recruitment will be performed as follows: ventilation will be set to pressure control mode and the driving pressure maintained at 10 cmH2O with an initial PEEP of 5 cmH2O, respiratory rate 8-10, I:E 1-1PEEP will be then increased by 5 cmH2O ev¬ery 30 s until the Ppeak reached 30 cmH2O (so peep will reach 20), held for 30 s , then PEEP will be gradually reduced at intervals of 5 cmH2O down to 5 cmH2O, when initial volume control ventilation will be resumed. In the incremental PEEP group, PEEP was increased stepwise by 5 cmH₂O every 3-5 breaths until a peak airway pressure of 30 cmH₂O was achieved, after which mechanical ventilation was resumed with maintenance PEEP. The total duration of the recruitment maneuver was approximately 60-90 seconds.

Interventions

PROCEDUREsustained inflation recruitement

anesthesiologist adjust the ventilator to manual ventilation mode and ad¬just The ventilator was switched to manual mode, and the airway pressure-limiting valve was set to 30 cmH₂O. A sustained manual inflation was then applied by gradually squeezing the anesthesia reservoir bag over 3-5 seconds until a peak airway pressure (Ppeak) of 30 cmH₂O

PROCEDUREStepwise PEEP

: ventilation will be set to pressure control mode and the driving pressure maintained at 10 cmH2O with an initial PEEP of 5 cmH2O, respiratory rate 8-10, I:E 1-1PEEP will be then increased by 5 cmH2O ev¬ery 30 s until the Ppeak reached 30 cmH2O

Sponsors

Ain Shams University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

1. Anesthesiologists (ASA) physical status II, of either sex Age ≥18 y. 2. Undergoing laparoscopic bariatric surgeries; sleeve gastrectomy, mini gastric bypass 3. BMI (35-60)

Exclusion criteria

1. Pre-existing severe pulmonary disease 2. Baseline hypoxemia SpO₂ \<92% on room air 3. History of barotrauma 4. Previous pneumothorax 5. Known pulmonary bullae or emphysematous blebs

Design outcomes

Primary

MeasureTime frameDescription
Postoperative lung aerationin the post-anesthesia care unit 15 minutes after extubationlimited-zone lung ultrasound scoring system

Secondary

MeasureTime frameDescription
Postoperative oxygenationin the post-anesthesia care unit 15 minutes after extubationSpO₂
Oxygen requirement in PACUin the post-anesthesia care unit 15 minutes after extubationto maintain SpO₂ ≥94%.

Countries

Egypt

Contacts

CONTACTamr fouad, M.D
amr_foud@med.asu.edu.eg01225674370

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Apr 14, 2026