Neuromuscular Blocking Agents
Conditions
Keywords
Neuromuscular Monitoring, Mivacurium, Neostigmine, Neuromuscular Blocking Agents
Brief summary
In this study, the antagonism of neostigmine, a cholinesterase inhibitor, on continuous infusion of mivacurium during foot and ankle surgery under general anesthesia was investigated, and the appropriate time point of antagonism was explored.
Detailed description
Mivacurium is currently the shortest-acting benzylisoquinoline nondepolarizing muscular relaxant in clinical practice, which is suitable for short surgery. Its continuous infusion can also be used in medium-term surgery with uncertain operation time, which can accelerate the recovery of postoperative muscle relaxation. Whether continuous infusion of mivacurium requires antagonism and the appropriate time point of antagonism is controversial.
Interventions
DRUGNeostigmine
Administer neostigmine at a dose of 0.04 mg/kg (combined with 0.02 mg/kg atropine)
Sponsors
Beijing Tongren Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* 18 - 65 years old; * American Society of Anesthesiologists (ASA) physical stastus classification system: I-II; * Body mass index (BMI) 18.5 - 30 kg/m2 * Patients with normal cholinesterase levels before the operation
Exclusion criteria
* Refusal to participate in the study; * ASA classification of grade III or above; * Severe organ dysfunction, difficult airway or neurological muscle disorders; * Taking drugs that affect neuromuscular monitoring or neuromuscular conduction function; * Allergic to the test drug or having other contraindications; * Pregnant and lactating women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The time from count 2 to TOFr recovery to 0.9 | Perioperative |
Secondary
| Measure | Time frame |
|---|---|
| The time from count 2 to TOFr recovery to 0.7 | Perioperative |
| The time from count 2 to TOFr recovery to 0.4 | Perioperative |
| Mean Arterial Pressure | Perioperative |
| Blood pressure | Perioperative |
| Heart rate | Perioperative |
| Surgical duration | The start time and end time of the surgery |
Countries
China
Contacts
CONTACTHaiyao Wu
STUDY_DIRECTORGuyan Wang
Beijing Tongren Hospital
Outcome results
None listed