Conditions
Conditions
Brief summary
Comparison of the effectiveness of nerve hydrodissection with saline injection of 5% dextrose in carpal tunnel syndrome.
Detailed description
Evaluation of pain, hand function, electrophysiological and ultrasonographic effects when comparing 5% dextrose saline injection via nerve hydrodissection under ultrasound guidance in mild to moderate carpal tunnel syndrome.
Interventions
DRUGNerve Hydrodissection with 5% Dextrose
Injection therapy
Sponsors
Antalya Training and Research Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Adults aged 18-80 years * Clinical and electrophysiological diagnosis of mild to moderate carpal tunnel syndrome * Symptom duration of at least 3 months * Both male and female participants * Patients who have not responded adequately to conservative treatment * Patients who do not wish to undergo surgical treatment * Ability to provide informed consent
Exclusion criteria
* Severe or very severe carpal tunnel syndrome based on EMG findings * Previous injection therapy for carpal tunnel syndrome * Prior wrist or carpal tunnel surgery * Polyneuropathy or other peripheral neuropathies * Cervical radiculopathy or proximal median nerve entrapment * Brachial plexopathy or thoracic outlet syndrome * Pregnancy * Malignancy * Local or systemic infection * Cognitive impairment affecting cooperation * Systemic diseases affecting the median nerve (e.g., uncontrolled diabetes mellitus, thyroid disorders)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in pain intensity measured by Visual Analog Scale (VAS) | Baseline to 8 month | The primary outcome is the change in pain intensity assessed by the Visual Analog Scale (VAS, 0-10). The difference between baseline and follow-up scores will be analyzed. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in Qucik DASH score | Baseline to 8 month | Assessed using symptom severity and functional status scales |
| Change in median nerve cross-sectional area | Baseline to 8 month | Measured at the carpal tunnel inlet using ultrasonography |
| hange in nerve conduction study parameters | Baseline to 8 month | Distal motor latency and sensory conduction velocity of the median nerve |
| Change in hand grip strength | Baseline to 8 month | Strength of the arm |
Countries
Turkey (Türkiye)
Outcome results
None listed