Alzheimer Disease, App-based Cognitive Training, Mild Cognitive Impairment, Old Age; Dementia, Remote Cognitive Training, Serious Games
Conditions
Keywords
Alzheimer's Disease, Remote technology, Cognitive training, Old Age Psychiatry
Brief summary
The investigators are adapting a tablet-based cognitive training program for Alzheimer's disease (AD) by focusing on specific cognitive components. It is aimed to demonstrate the feasibility, acceptability and usability of remote cognitive training in older adults with Mild Cognitive Impairment (MCI) and AD dementia. The study involves 36 participants in three groups, with a two-week intervention and focus groups for refinement.
Detailed description
The investigators aim to extend a tablet-computer-based cognitive training (CT), fully developed in house (KEK 2020-00630), and tailored specifically towards a "typical-AD" cognitive component. This cognitive component is defined through a principal-component analysis (PCA), on which the domains affected by AD (episodic memory, spatial processing, semantic memory) have high loadings. The investigators moreover train working memory training to facilitate transfer effects. By including carers (family members, friends, professional carers) in the focus groups and the integration of help buttons, the investigators expect high adherence. The CT will be based on our ongoing study assessing the CT in people at risk for AD and subjective cognitive decline. The investigators plan a small feasibility study in three different groups with a total of 36 elderly participants including cognitively normal (N=12), MCI (N=12), and mild-moderate stage dementia due to AD (N=12). The focus will be on qualitative content analyses based on the results from the focus groups. The results from the first focus group sessions serve the selection, adaptation, and improvement of the CT before it is implemented in the two-week intervention including daily 30-minutes training sessions. A second focus group after the intervention will serve to gain additional insights from users and carers to further improve the CT. To complement this information, the investigators will quantitatively compare specific game parameters related to feasibility (number of levels achieved, numbers of sessions finished, number of dropouts), usability (time until reaching level 1 - learn duration, numbers of help button presses), and acceptability (game evaluation) between the three treatment groups. The investigators aim to demonstrate that remote CT is possible in older adults with Mild Cognitive Impairment (MCI) and diagnosed AD dementia at home and in the care home setting by extending an existing tablet-based CT app with additional (easier) training levels, additional and detailed introductory material to also allow cognitively more severely impaired participants to conduct the CT with as little external support as possible. This study is considered as Risk Category A. The study intervention consists of a tablet-based CT, which does not provide any known risks for the participants.
Interventions
DEVICEApp-based cognitive training
The cognitive training is administered remotely for 2 weeks daily (10 sessions). The participants play all 12 games for 8 minutes in each session.
Sponsors
University of Bern
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
70 Years to 95 Years
Healthy volunteers
Yes
Inclusion criteria
Participants and study partners fulfilling all the following inclusion criteria are eligible for the study: • Informed Consent as documented by signature Study partners: • Native or fluent German speaker Participants: * Are able to give their consent to participate in the study * Age between 70 and 95 years * Native or fluent German speaker * Normal or corrected to normal vision and hearing * Ability to visit the study location repeatedly * MoCA score \> 11
Exclusion criteria
* Substance abuse * Severe neurological or psychiatric conditions (of note: patients with mild depressive symptoms not fulfilling the criteria for major depressive disorder will be recruited into the sample to better represent clinical reality)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Feasibility of tablet-based cognitive training | Assessed at the end of the 2-week intervention (Day 10) | Compliance rate (i.e.number of sessions completed) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Feasibility of tablet-based cognitive training | Assessed at the end of the 2-week intervention (Day 10) | Number of levels achieved |
| Usability | Assessed at the end of the 2-week intervention (Day 10) | Time until accomplishment of the first level (learning time) |
| Acceptability | Assessed within two weeks after day 10 of the intervention | Qualitative evaluation of the games in a semi-structured interview (Focus group discussion). For each game, the same questions will be addressed in an open discussion. |
| 2. Feasibility of tablet-based cognitive training | Assessed at the end of the 2-week intervention (Day 10) | Number of drop-outs |
Countries
Switzerland
Contacts
STUDY_CHAIRAnna-Katharine Brem
University Hospiltal of Old Age Psychiatry and Psychotherapy
Outcome results
None listed