Serum Myostatin and Irisin Levels in Postmenopausal Women: Association With Bone Mineral Density and Muscle Strength

Evaluation of the Relationship Between Serum Myostatin and Irisin Levels and Bone Mineral Density and Muscle Strength in Postmenopausal Women

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07519551

Acronym

MYOIRISIN

Enrollment

Registered

2026-04-09

Start date

2026-04-03

Completion date

2026-05-30

Last updated

2026-04-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoporosis, Osteopenia

Brief summary

This study aims to evaluate the relationship between serum myostatin and irisin levels and bone mineral density and muscle strength in postmenopausal women. Participants will be grouped according to bone mineral density as normal, osteopenic, or osteoporotic. Serum myostatin and irisin levels will be measured, and muscle strength will be assessed using handgrip strength and the five times sit-to-stand test. The associations between biochemical and functional parameters will be analyzed.

Detailed description

This cross-sectional observational study aims to evaluate the relationship between serum myostatin and irisin levels and bone mineral density and muscle strength in postmenopausal women. Postmenopausal women aged between 50 and 65 years who meet the inclusion criteria will be enrolled in the study. Bone mineral density will be assessed using dual-energy X-ray absorptiometry (DEXA), and participants will be classified into three groups as normal, osteopenic, or osteoporotic according to T-scores. Serum myostatin and irisin levels will be measured from venous blood samples collected after overnight fasting. Muscle strength will be evaluated using handgrip strength, and functional performance will be assessed with the five times sit-to-stand test. Demographic and clinical characteristics of the participants will also be recorded. The relationships between serum myostatin and irisin levels and bone mineral density and muscle strength parameters will be analyzed using appropriate statistical methods.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

FEMALE

Age

50 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* Postmenopausal women aged between 50 and 65 years Availability of bone mineral density measurement by dual-energy X-ray absorptiometry (DEXA) Willingness to participate in the study

Exclusion criteria

* Presence of malignancy Chronic kidney disease Chronic liver disease Neuromuscular disorders Recent major surgery or trauma Use of medications affecting bone or muscle metabolism

Design outcomes

Primary

Measure	Time frame	Description
Relationship between serum myostatin and irisin levels and bone mineral density (T-score)	Baseline	Serum myostatin and irisin levels will be measured from fasting venous blood samples, and bone mineral density will be assessed using dual-energy X-ray absorptiometry (DEXA). The relationship between these parameters will be evaluated.

Secondary

Measure	Time frame	Description
Relationship between serum myostatin and irisin levels and muscle strength	Baseline	Muscle strength will be assessed using handgrip strength, and its relationship with serum myostatin and irisin levels will be evaluated.
Comparison of serum myostatin and irisin levels among bone mineral density groups	Baseline	Serum myostatin and irisin levels will be compared among normal, osteopenic, and osteoporotic groups defined by dual-energy X-ray absorptiometry (DEXA).

Contacts

CONTACTZeynep Karakuzu Güngör, M.D

zeynepkarakuzu@hotmail.com.tr+905077750375

PRINCIPAL_INVESTIGATORZeynep Karakuzu Güngör, M.D

Saglik Bilimleri Universitesi

Outcome results