Vasodilation, Exercise, Healthy Adults
Conditions
Keywords
Exercise, Vasodilation, Vinitrox
Brief summary
To evaluate the effect of acute polyphenols supplementation on vasodilation and related markers along with exercise related markers (notably performance, respiratory exchanges, perceived exertion), before, during and after a hypoxic moderate-intensity exercise in healthy recreative volunteers.
Detailed description
Exercise session is an ergometer cycling workout performed under hypoxia condition equivalent to 3000 meters of altitude. Exercise session is composed of a warmup period followed by 20 minutes of cycling starting at 60% of individual maximal aerobic power.
Interventions
DIETARY_SUPPLEMENTOral administration
2 capsules the day before and 2 capsules 2 hours before the exercise session
Sponsors
Nexira
CEP - Centre d'Expertise de la Performance Gilles Cometti
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
35 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
* BMI \< 27 * Abdominal circumference \< 94 cm * Stable exercise training program during past 2 months
Exclusion criteria
* Total weekly exercise sessions \< 4 hours OR \> 8 hours * Drug or supplement intake during past one month that could interfere with study parameters * Volunteer suffering of respiratory or pulmonary condition * Volunteer exposed to an altitude \> 2000 meters during at least 3 weeks for the past 6 months.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Flow mediated dilation (FMD ; %) | Before the exercise session (at rest under normoxia and hypoxia conditions) | Comparison of brachial artery diameter measured by ultrasound, before and after distal cuff-occlusion |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Fraction exhaled nitric oxyde (FeNO ; ppb) | Before the exercise session (at rest under normoxia and hypoxia conditions) / After the exercise session (under normoxia condition). | Exhaled breath, quantified by electrochemical analyzer |
| Oximetry (SpO2, %) | Before the exercise session (at rest under normoxia and hypoxia conditions) / During exercise session (5 minutes intervals) / After the exercise session (under normoxia condition) | finger captation |
| Muscular oximetry (SmO2, saturation index) | During exercise session (5 minutes intervals) / After the exercise session (under normoxia condition) | Rectus femoris muscle captation |
| Maximal power and Total work (watt) | During exercise session (5 minutes intervals) | Ergometer |
| Respiratory gas exchanges (VO2, VCO2 ; mL/min/kg)) | Before the exercise session (at rest under normoxia and hypoxia conditions) / During exercise session (5 minutes intervals) / After the exercise session (under normoxia condition) | Gas mask |
| Respiratory exchange ratio (RER) | Before the exercise session (at rest under normoxia and hypoxia conditions) / During exercise session (5 minutes intervals) / After the exercise session (under normoxia condition) | Gas mask |
| Heart rate (bpm) | Before the exercise session (at rest under normoxia and hypoxia conditions) / During exercise session (5 minutes intervals) / After the exercise session (under normoxia condition) | Thoracic belt |
| Blood pressure (mmHg) | Before the exercise session (at rest under normoxia and hypoxia conditions) / During exercise session (5 minutes intervals) / After the exercise session (under normoxia condition) | Wirst captation |
| Lactatemia (mmol/L) | During exercise session (5 minutes intervals) / After the exercise session (under normoxia condition) | enzymo-amperometric ; fingertip |
| Perceived exertion (1-10 scale) | During exercise session (5 minutes intervals) | Borg scale |
Countries
France
Outcome results
None listed