Neural Synchronization During Gesture Production and Comprehension in Individuals With Aphasia and Healthy Controls: A Study Using EEG Hyperscanning

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07518563

Acronym

RIAB_GESTO

Enrollment

Registered

2026-04-08

Start date

2022-06-01

Completion date

2023-08-01

Last updated

2026-04-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aphasia, Gestures, Stroke

Keywords

gestures, aphasia, EEG, hyperscanning

Brief summary

This study explores the neural mechanisms of gesture comprehension and production in people with aphasia (PWA) and healthy controls, focusing on brain synchronization during gesture observation and reproduction. Using EEG hyperscanning, neural coupling between the encoder (PWA) and decoder (healthy participant) was analyzed during tasks involving social, affective, and informative gestures with both positive and negative emotional valence.

Detailed description

Gestures are essential in non-verbal communication, complementing speech by expressing emotions, intentions, and cognitive states. This study examines neural mechanisms of gesture comprehension and production in people with aphasia (PWA) and healthy controls, focusing on brain synchronization during gesture observation and reproduction. Using EEG hyperscanning, we analyzed neural coupling between the encoder (PWA) and decoder (healthy participant) during tasks involving social, affective, and informative gestures with both positive and negative emotional valence. Methods: Seven dyads of participants participated in this study. The research was approved by the Ethical Committee of the IRCCS San CamilloHospital

Interventions

BEHAVIORALPerson with Aphasia

EEG during gestures production

Study design

Observational model

COHORT

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

Age ≥ 18 years Diagnosis of left-sided stroke Clinical diagnosis of aphasia Native language: Italian (L1 Italian)

Exclusion criteria

History of psychiatric disorders

Design outcomes

Primary

Measure	Time frame	Description
neural synchronization	during EEG hyperscanning recording	Neural synchronization between encoder and decoder Description: Synchronization of activity in the alpha, beta, delta, and theta EEG bands between the encoder and decoder, assessed during task performance. Metrics will be reported separately for each frequency band. Time Frame: At EEG recording

Countries

Italy

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Apr 23, 2026