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Sunflower and Olive Oils for Preventing Diaper Dermatitis in Hospitalized Infants

The Effect of Sunflower and Olive Oils on Diaper Dermatitis in Hospitalized Infants Treated With Antibiotics: A Quasi-Experimental Study

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07517003
Acronym
DD-OIL
Enrollment
150
Registered
2026-04-08
Start date
2024-01-20
Completion date
2024-07-31
Last updated
2026-08-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diaper Dermatitis

Keywords

Infant, Sunflower oil, Olive oil, Diaper rash, Antibiotics

Brief summary

This quasi-experimental study aimed to evaluate the effects of sunflower oil and olive oil on the development of diaper dermatitis in hospitalized infants receiving antibiotic therapy. Infants aged 0-24 months were assigned to sunflower oil, olive oil, and control groups. Oils were applied to the diaper area after each diaper change. Infants were followed daily for 3-7 days, and diaper dermatitis severity was assessed using a four-stage clinical classification. The incidence of diaper dermatitis was compared between groups.

Detailed description

Diaper dermatitis is a common skin condition in infants and occurs more frequently in hospitalized infants receiving systemic antibiotics. This quasi-experimental study evaluated the preventive effects of sunflower oil and olive oil on diaper dermatitis. The study included 150 infants aged 0-24 months hospitalized and receiving antibiotic therapy. Participants were assigned to three groups: sunflower oil, olive oil, and control. In the intervention groups, oils were applied to the diaper area after each diaper change, while the control group received routine care. Infants were followed daily for 3-7 days, and diaper dermatitis severity was assessed using a four-stage clinical classification. The primary outcome was the incidence of diaper dermatitis. The study aimed to determine whether sunflower oil and olive oil reduce diaper dermatitis in hospitalized infants.

Interventions

OTHERSunflower Oil

Sunflower oil applied to the diaper area after each diaper change during hospitalization.

OTHEROlive Oil

Olive oil applied to the diaper area after each diaper change during hospitalization.

OTHERRoutine Care

Routine diaper care without topical oil application during hospitalization.

Sponsors

Dicle University
Lead SponsorOTHER

Study design

Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE

Intervention model description

Participants were assigned to three parallel groups: sunflower oil, olive oil, and routine care control. Oils were applied after each diaper change during hospitalization.

Eligibility

Sex/Gender
ALL
Age
0 Months to 24 Months
Healthy volunteers
No

Inclusion criteria

* Infants aged 0-24 months * Hospitalized and receiving systemic antibiotic therapy * Expected hospital stay of 3-7 days * Using disposable diapers * Written informed parental consen

Exclusion criteria

* Premature or low birth weight infants * Existing diaper dermatitis * Diarrhea or oral candidiasis * Chronic skin diseases (eczema, atopy, seborrheic dermatitis) * Receiving antifungal treatment * Neurological or urological anomalies * Use of urinary catheter or bag * Toilet-trained infants

Design outcomes

Primary

MeasureTime frameDescription
Incidence of diaper dermatitisDuring hospitalization (3 days up to 7 days)Incidence of diaper dermatitis assessed using diaper dermatitis severity scoring system in hospitalized infants receiving sunflower oil, olive oil, or routine care.

Secondary

MeasureTime frameDescription
Four-grade clinical classification described by Kırçuval (2001)During hospitalization (3-7 days)Diaper dermatitis severity was assessed daily using the four-grade clinical classification described by Kırçuval (2001). Severity ranges from Grade I to Grade IV (1-4). Grade I indicates mild erythema limited to the diaper area; Grade II indicates marked erythema with lesions or desquamation limited to the diaper area; Grade III indicates marked erythema extending to the inner thighs and abdomen; and Grade IV indicates severe erythema with erosion and pustules. Higher grades indicate greater diaper dermatitis severity and therefore a worse outcome.

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Aug 28, 2026