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Multimodal Phenotyping In Patients Referred With Acute Cardiac faiLurE

Multimodal Phenotyping In Patients Referred With Acute Cardiac faiLurE

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT07515508
Acronym
MIRACLE
Enrollment
600
Registered
2026-04-07
Start date
2024-08-07
Completion date
2028-07-31
Last updated
2026-07-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Heart Failure (AHF), Cardiogenic Shock

Brief summary

The goal of this observational study is to learn whether information collected during routine hospital care, together with blood and urine samples, can help doctors better identify different types of cardiogenic shock and better predict outcomes in adults hospitalized with acute heart failure and cardiogenic shock. The main question is whether clinical findings, imaging results, and biomarkers, including sex-specific factors, are associated with the risk of death within 30 days. Participants will not receive an experimental treatment. Researchers will collect data from routine care, collect additional blood and urine samples for biobanking, and follow participants after hospital discharge

Interventions

None listed

Sponsors

University Heart Center Freiburg - Bad Krozingen
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Patients hospitalized with acute heart failure SCAI stage B - E.

Exclusion criteria

* Not capable of providing informed consent due to reasons not attributable to cardiogenic shock * Cardiogenic shock following cardiothoracic surgery

Design outcomes

Primary

MeasureTime frame
Mortality30 days

Secondary

MeasureTime frame
Mortality6 and 12 months
Rehospitalization for heart failureFrom hospital discharge until 12 months
Rehospitalization for cardiac reasons (non-elective)From hospital discharge until 12 months

Countries

Germany

Contacts

CONTACTLucas Bacmeister, MD
lucas.bacmeister@uniklinik-freiburg.de004976127034010

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Jul 30, 2026