Cardiac Surgery Subjects
Conditions
Keywords
pain threshold, intra operative opioid consumption, algometer
Brief summary
The study aims to test the relationship between the preoperative pain threshold and the intraoperative need for opioids. The objective of the study is to try to predict a patient's analgesic needs based on their objectively determined preoperative pain threshold. The investigators will include patients scheduled for elective cardiovascular surgery. The investigators will investigate the correlation between the preoperative pain threshold and intraoperative/postoperative opioid consumption in a highly standardized anesthesia setting.
Interventions
DEVICEMeasure of the minimal pain threshold with an algometer
The measure of the minimal pain threshold is taken the day before the cardiac surgery
Sponsors
Université Libre de Bruxelles
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* ASA 3 patients with scheduled cardiac surgery by thoracotomy or sternotomy
Exclusion criteria
* Patient refusal, * A body mass index (BMI) \> 30 kg/m², * Allergies to any medication used in typical cardiac anesthesia, * Chronic pain or regular use of analgesics, * Severe ventricular dysfunction, pulmonary hypertension, poorly controlled arhythmia, * Non-elective surgery. * Patients enrolled in another study protocol within the previous 3 months, * Pregnant or breastfeeding patients, * Patients with severe renal or hepatic impairment. * Patients for whom the study will be stopped in the event of blood loss greater than or equal to one liter, or for any other severe perioperative surgical complication.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Correlation between the pressure pain threshold and the consumption of opioid during and after the surgery | From enrollment to the end of opioid administration during hospital stay, up to 6 days after the enrollment | After the measure of the minimal pain threshold the day before the surgery, the investigators look at the quantity of Remifentanil which has been given to the patient during the surgery. Then they will look for a correlation |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Correlation between the pain threshold and the consumption of morphine during the post-operative time | From enrollment to the end of opioid administration during hospital stay, up to 6 days after the enrollment | After the measure of the minimal pain threshold the day before the surgery, the investigators look at the quantity of morphine which has been administrated by a PCA (Intravenous Patient-Controlled Analgesia (IV-PCA) with morphine) to the patient during the post-operative time. Then they are looking for a correlation. |
Countries
Belgium
Contacts
CONTACTIONUT TABOLCEA, Doctor
CONTACTNATHAN ASSERAF
PRINCIPAL_INVESTIGATORIONUT TABOLCEA, Doctor
Erasme University Hospital
Outcome results
None listed