Overactive Bladder, Vitamin D Deficiency
Conditions
Brief summary
The primary aim of this study is to evaluate the role of three specific urinary proteins-RhoA, Nerve Growth Factor (NGF), and Brain-Derived Neurotrophic Factor (BDNF)-as potential biomarkers for the diagnosis and follow-up of children aged 4-18 diagnosed with Overactive Bladder (OAB) and Vitamin D deficiency.
Interventions
BEHAVIORALUrotherapy
Diagnosis and first-line treatment (urotherapy) will be conducted per European Association of Urology (EAU) guidelines.
Sponsors
Tarik Emre Sener
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
No minimum to 18 Years
Healthy volunteers
Yes
Inclusion criteria
* Children aged 4-18 years presenting with active OAB symptoms (frequency, urgency)
Exclusion criteria
* Neurological diseases * Malignancy * Active urinary tract infections * Anatomical bladder anomalies * History of prior OAB treatment/urological surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in Urinary Biomarker Levels: * Quantitative measurement of urinary RhoA, NGF (Nerve Growth Factor), and BDNF (Brain-Derived Neurotrophic Factor) levels using the ELISA method. | One year |
Secondary
| Measure | Time frame |
|---|---|
| Clinical Symptom Improvement: * Reduction in LUTS (Lower Urinary Tract Symptoms) based on standardized voiding dysfunction symptom scores. | One year |
Countries
Turkey (Türkiye)
Contacts
CONTACTHamza Tunahan Midilli
Outcome results
None listed