Leukemia, Myelomonocytic Leukemia, Chronic
Conditions
Brief summary
A prospective, non-interventional study involving the collection of biological samples with associated anonymised data. Biological samples will be collected at the time of diagnosis and/or as the disease progresses, with or without treatment, always in conjunction with tests scheduled as part of routine care or within the context of a clinical trial.
Interventions
BIOLOGICALSampling
Blood samples taken as part of a scheduled assessment within the context of medical care * Standard sample: 2 x 10 mL EDTA tubes * For the initial assessment: 1 x 10 mL dry tube At the request of the research teams: one EDTA tube may be replaced by a heparinised or citrated tube, depending on the planned research. Bone marrow samples, taken during a scheduled myelogram as part of medical care * Myelogram: 1 x 2 mL EDTA tube In exceptional cases, during a scheduled surgical procedure, a tissue sample will be considered in consultation with the surgeon (affected tissue, surrounding healthy tissue).
Sponsors
Gustave Roussy, Cancer Campus, Grand Paris
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adults aged 18 years and over * Blood monocytosis ≥ 0.5 × 10⁹/L and ≥ 10% of total white blood cells or * Confirmed diagnosis of chronic myelomonocytic leukemia * Regardless of stage (chronic or transformed), and whether or not currently being treated * Signed informed consent
Exclusion criteria
* Active, uncontrolled infection (particularly hepatitis B, hepatitis C, HIV) * Refusal informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Understanding the pathophysiology of chronic myelomonocytic leukaemia | through study completion, an average of 15 years | optimise diagnosis, improve prognostic stratification, identify new treatment options and assess patients' response to proposed treatments through the analysis of blood or bone marrow samples collected as part of routine care or clinical trials |
Countries
France
Contacts
CONTACTChristophe WILLEKENS
CONTACTEric SOLARY
Outcome results
None listed