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Piriformis and Gluteal Muscle Thickness in Patients With Unilateral Greater Trochanteric Pain Syndrome

Observational Assessment of Deep Gluteal Syndrome and Bilateral Piriformis, Gluteus Medius, and Gluteus Maximus Muscle Thickness Using Ultrasonography in Patients With Unilateral Greater Trochanteric Pain Syndrome

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT07510763
Enrollment
60
Registered
2026-04-03
Start date
2025-12-02
Completion date
2026-03-31
Last updated
2026-04-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Deep Gluteal Syndrome, Gluteal Tendinopathy, Greater Trochanteric Pain Syndrome

Keywords

Greater Trochanteric Pain Syndrome, Musculoskeletal Ultrasound, Deep Gluteal Syndrome, Hip Pain, Muscle Thickness, Piriformis Muscle, Gluteal Muscle Thickness

Brief summary

This study aims to evaluate muscle thickness in patients with unilateral Greater Trochanteric Pain Syndrome using ultrasonography and to compare these findings with healthy individuals. The primary objective is to determine whether piriformis muscle thickness differs between patients and controls. Secondary objectives include assessing gluteus medius and gluteus maximus muscle thickness, side-to-side differences in piriformis and gluteal muscle thickness, and the presence of Deep Gluteal Syndrome.

Detailed description

This observational cross-sectional study investigates ultrasonographic muscle morphology and associated clinical findings in patients with unilateral Greater Trochanteric Pain Syndrome (GTPS), focusing on piriformis and gluteal muscle thickness, symptom severity, and Deep Gluteal Syndrome-related findings. Participants with unilateral GTPS and healthy controls are recruited from outpatient clinical settings. The clinical diagnosis of Greater Trochanteric Pain Syndrome is based on the presence of lateral hip pain in combination with at least two of the following findings: tenderness over the greater trochanter on palpation, pain during a 30-second single-leg stance test, or supportive ultrasonographic findings. Ultrasonographic evaluations are performed bilaterally to measure piriformis, gluteus medius, and gluteus maximus muscle thickness. For each muscle, three measurements are obtained, and the mean value is used for analysis. Inter-side differences between affected and unaffected hips in the GTPS group and between both hips in the control group are calculated to assess asymmetry. In the control group, the mean values of both hips are calculated and used as reference values. Comparisons are performed between affected and unaffected hips within the patient group. In addition, muscle thickness of the affected and unaffected hips in the GTPS group is compared separately with the control group mean values for each muscle. Inter-side differences in muscle thickness are also compared between patients and healthy controls. Trochanteric bursal fluid and Doppler signal changes are also evaluated using ultrasonography. The presence of Deep Gluteal Syndrome is determined based on clinical criteria, defined as at least one clinical finding together with at least two positive standardized clinical provocation tests. Patients are categorized as Deep Gluteal Syndrome-positive or negative accordingly. Symptom severity is assessed using the VISA-G (Victorian Institute of Sport Assessment-Gluteal) questionnaire. Correlation analyses are performed to evaluate the association between VISA-G scores and inter-side differences in muscle thickness.

Interventions

None listed

Sponsors

Ankara Etlik City Hospital
Lead SponsorOTHER_GOV

Study design

Observational model
COHORT
Time perspective
CROSS_SECTIONAL

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes

Inclusion criteria

* Adults aged 18 years or older * Diagnosis of unilateral Greater Trochanteric Pain Syndrome

Exclusion criteria

* Presence of lumbar radiculopathy * Presence of hip or spinal osteoarthritis * History of lumbar spine or lower extremity surgery * Presence of neurological disorders affecting muscles or peripheral nerves * Pregnancy * Presence of cognitive impairment or neuropsychiatric conditions limiting participation * Unwillingness to participate * Regular participation in physical exercise (defined as more than two sessions per week)

Design outcomes

Primary

MeasureTime frameDescription
Piriformis Muscle ThicknessAt baselineComparison of piriformis muscle thickness between patients with unilateral Greater Trochanteric Pain Syndrome and healthy controls using ultrasonography

Secondary

MeasureTime frameDescription
Gluteus Medius and Gluteus Maximus Muscle ThicknessAt baselineComparison of gluteus medius and gluteus maximus muscle thickness between patients with unilateral Greater Trochanteric Pain Syndrome and healthy controls using ultrasonography.
Side-to-Side Muscle Thickness ComparisonAt baselineWithin-group comparison of piriformis, gluteus medius, and gluteus maximus muscle thickness between affected and unaffected sides in patients with unilateral Greater Trochanteric Pain Syndrome.
Trochanteric Bursa and Doppler FindingsAt baselineAssessment of trochanteric bursal fluid and Doppler signal changes in patients with Greater Trochanteric Pain Syndrome using ultrasonography.
Prevalence of Deep Gluteal SyndromeAt baselineAssessment of the presence of Deep Gluteal Syndrome in patients with Greater Trochanteric Pain Syndrome based on clinical evaluation and standardized provocation tests.
Correlation Between VISA-G Score and Hip Muscle Thickness AsymmetryAt baselineCorrelation between VISA-G score and inter-side muscle thickness differences of piriformis, gluteus medius, and gluteus maximus measured by ultrasonography in the patient group.
Inter-side difference in muscle thickness between patients and controlsAt baselineComparison of inter-side differences in piriformis, gluteus medius, and gluteus maximus muscle thickness between patients with unilateral Greater Trochanteric Pain Syndrome and healthy controls using ultrasonography

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Apr 14, 2026