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Integrating Sexual Pleasure Into Harm Reduction Services for Men Who Have Sex With Men and Transgender Persons Who Engage in Chemsex or Substance Use in Thailand

Integrating Sexual Pleasure Into Harm Reduction Services for Men Who Have Sex With Men and Transgender Persons Who Engage in Chemsex or Substance Use in Thailand

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07509853
Acronym
PLEASURE
Enrollment
300
Registered
2026-04-03
Start date
2025-05-01
Completion date
2028-05-01
Last updated
2026-04-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chemsex, HIV Prevention, Mental Health, Sexually Transmitted Infections (STIs), Substance Use

Keywords

PrEP, Harm reduction, Chemsex, Transgender, Sexual pleasure

Brief summary

The study evaluates the integration of a sexual pleasure-based approach into harm reduction services for MSM and transgender persons engaging in chemsex or substance use in Thailand, using the "Pleasuremeter" tool to improve sexual health and related outcomes.

Detailed description

This is a sequential exploratory mixed-methods implementation study conducted at IHRI clinics in Bangkok. The study includes a pre-implementation phase (qualitative interviews) and an implementation phase where the adapted "Pleasuremeter" is integrated into harm reduction services. Approximately 300 participants will be enrolled and followed at baseline, month 3, and month 6. Outcomes include sexual pleasure, behavioral risk, substance use, HIV/STI testing, mental health, and socio-legal factors. The study also evaluates acceptability, satisfaction, and feasibility of integrating a pleasure-based approach into existing services.

Interventions

BEHAVIORALPleasuremeter-guided qualitative interview

Semi-structured in-depth interviews guided by the Pleasuremeter framework, covering 7 domains of sexual pleasure: * Physical and psychological satisfaction * Self-determination * Consent * Safety * Privacy * Confidence * Communication/negotiation

BEHAVIORALPleasuremeter-based sexual pleasure discussion integrated with harm reduction services

Participants will undergo: * Sexual pleasure assessment using Pleasuremeter (0-10 scale, 3-month recall) * Behavioral risk and substance use assessment * HIV/STI testing * Mental health screening using Electronic Mental Wellness Tool (e-mwTool) * Social and stigma assessment * Harm reduction services (drug literacy, counseling, referral, harm reduction kits) The intervention aims to facilitate structured discussions on sexual pleasure within harm reduction services.

Sponsors

Institute of HIV Research and Innovation Foundation, Thailand
Lead SponsorOTHER

Study design

Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* MSM, transgender women, transgender men, or non-binary persons * Age ≥18 years * Engaged in chemsex or substance use within past 12 months * Able to provide informed consent

Exclusion criteria

• Unable to communicate in Thai sufficiently to complete study procedures

Design outcomes

Primary

MeasureTime frameDescription
Willingness to engage in sexual pleasure discussions assessed using the Pleasuremeter toolBaseline, Month 3, and Month 6 (over 6 months follow-up)The primary outcome is the proportion of participants who agree to engage in structured discussions on sexual pleasure using the Pleasuremeter, a structured assessment tool covering 7 domains: * Physical and psychological satisfaction * Self-determination * Consent * Safety * Privacy * Confidence * Communication/negotiation Willingness will be assessed at each study visit (baseline, month 3, month 6) based on participant acceptance or refusal to complete the Pleasuremeter assessment.
Sexual pleasure score assessed by the Pleasuremeter (0-10 scale)Baseline, Month 3, and Month 6Sexual pleasure will be measured using the Pleasuremeter, a composite self-reported scale assessing 7 domains of sexual experience. * Scale range: 0 to 10 * Minimum value: 0 (lowest level of sexual pleasure) * Maximum value: 10 (highest level of sexual pleasure) * Interpretation: Higher scores indicate better sexual pleasure and satisfaction Scores may be analyzed as: * Overall composite score * Domain-specific scores

Countries

Thailand

Contacts

CONTACTNittaya Phanuphak, MD,PhD.
nittaya.p@ihri.org6681 825 3544
CONTACTAkarin Hiransuthikul, MD,MSc
akarin.h@chula.ac.th662 252 7864
PRINCIPAL_INVESTIGATORAkarin Hiransuthikul, MD,MSc

Chulalongkorn University

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Apr 9, 2026