Echocardiography-derived Pre-induction Hemodynamic Phenotypes and Post-induction Hypotension: an Exploratory Clustering Analysis

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07509255

Enrollment

Registered

2026-04-03

Start date

2020-02-01

Completion date

2020-03-30

Last updated

2026-04-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post-induction Hypotension (PIH)

Keywords

General anaesthesia, Transthoracic echocardiography, Post-induction hypotension, Hemodynamic phenotypes

Brief summary

This study evaluated the occurrence of post-induction hypotension (PIH) in patients undergoing elective surgery under general anesthesia. PIH is a common perioperative complication associated with adverse outcomes. Using previously collected clinical and echocardiographic data, the study explored the relationship between pre-induction hemodynamic status and the risk of developing PIH. The findings may help improve preoperative risk stratification and support more individualized perioperative hemodynamic management.

Detailed description

Post-induction hypotension (PIH) was recognized as a common and clinically significant complication associated with adverse perioperative outcomes. This study was conducted as a retrospective analysis of prospectively collected data from adult patients undergoing elective surgery under general anesthesia. The objective was to evaluate whether pre-induction hemodynamic status, assessed using echocardiographic parameters and routine clinical variables, was associated with the occurrence and timing of PIH. The analysis focused on identifying distinct hemodynamic profiles reflecting underlying cardiovascular physiology. Unsupervised clustering (k-means) was applied to pre-induction variables to identify phenotypes, and principal component analysis was used to explore variable contributions. Latent profile analysis was performed as a sensitivity analysis. The association between phenotypes and PIH was assessed using time-to-event analysis. No additional interventions were performed, and patient management was not influenced by the study. All analyses were conducted on anonymized data. This study aimed to improve the understanding of variability in hemodynamic responses to anesthesia induction and to support future strategies for individualized perioperative care.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

50 Years to No maximum

Healthy volunteers

Inclusion criteria

Patients scheduled for elective abdominal surgery under genral anesthesia.

Exclusion criteria

* patients with dyspnoea * unstable angina, * severe valvular heart disease * anticipated or unanticipated difficult airway management * suspected increased intra-abdominal pressure * poor echogenicity.

Design outcomes

Primary

Measure	Time frame	Description
Pre-induction hemodynamic phenotype classification	pre-induction, before administration of general anesthesia: from admission to the operating to induction of general anesthesia	Pre-induction hemodynamic phenotypes were derived using unsupervised clustering of clinical and echocardiographic variables obtained prior to anesthesia induction.

Countries

Morocco

Outcome results