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A Digitally-Enabled System for Precision Assessment and Intervention of Disability Risk in Older Adults

The Construction of a Digitally-Enabled Precision Assessment and Intervention System for Disability Risk in Older Adults and a Full-Cycle, Multi-Scenario Demonstration Study

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07508813
Enrollment
238
Registered
2026-04-02
Start date
2025-10-31
Completion date
2026-12-30
Last updated
2026-04-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Disability

Keywords

older adults, disability, prevention, risk

Brief summary

1. Identify the primary risk factors for disability in older adults through multi-dimensional risk factor screening. 2. Develop a risk stratification model for disability in older adults by integrating outcome indicators and temporal characteristics, and construct an intelligent early warning model to enable automated assessment and monitoring of disability risk. 3. Establish key digital technologies for early warning and prevention of disability risk in older adults, and develop a whole-process digital intervention platform incorporating a decision support system for disability prevention management. 4. Create a digitally empowered hospital-community-household collaborative system for precise assessment and intervention of disability risk in older adults, achieving data-driven whole-process active disability management. The system will be demonstrated and evaluated in communities with diverse characteristics across urban, county, and rural settings.

Detailed description

1. Multidimensional Risk Factor Screening and Identification of Key Risk Factors for Disability in Older Adults: Health records from a cohort of 100,000 urban and rural older adults in Zhejiang Province between 2018 and 2022 were reviewed. Data indicators including demographics, disease characteristics, cognitive psychological assessments, and family-social factors were extracted. Disability in older adults was used as the outcome variable to preliminarily screen risk factors, forming a multidimensional indicator set for disability risk. Principal component analysis was applied to identify disability risk syndromes. The Elastic Net model was employed to further extract major risk factors, and full-cycle key risk factors for disability were determined based on five-year risk exposure characteristics. 2. Construction of a Time Series-Based Risk Stratification and Early Warning Model for Disability in Older Adults:Integrating full-cycle disability characteristics (such as disability severity, features, and time points) as primary outcome indicators. Apply weighting and clustering decisions based on key risk factors to achieve risk stratification and identification. Define key risk factor abnormalities, risk syndromes, disability risk, and actual disability occurrence as monitoring nodes, corresponding to zero-level, level-one, level-two, and level-three warning tiers respectively. By integrating time-series features, a Long Short-Term Memory (LSTM) neural network model is constructed to develop an incapacitation risk early warning system. 3. Development of Digital Diagnosis and Treatment Technologies for Early Warning and Prevention of Disability Risk and Construction of an Intervention Decision Support System:Based on evidence-based medicine, multi-scenario disability prevention requirements, and expert consensus, a big data knowledge database and technology library for disability prevention and control wiil be established. The logical framework, technical architecture, and functional design of the disability risk intervention decision support system will be systematically planned, forming a knowledge graph network related to disability. Integrating modules for elderly disability risk assessment and dynamic monitoring, an internet-based technical module for elderly disability management will be established. This covers the entire process from information collection, assessment and monitoring, to early warning decision-making and targeted interventions. The system will be deeply integrated and optimised with the 'Internet Plus Nursing' platform to construct a digitalised elderly disability risk intervention platform. 4. Application of the Precision Assessment and Intervention System for Disability Risks in the Elderly: Conducting standardized demonstration research on disability prevention and control bases using this system. Establish demonstration bases in cities, counties, and townships across Zhejiang Province to develop standardized protocols for preventing disability among the elderly through coordinated efforts between hospitals, communities, and households.Based on data-driven to optimize staffing, service processes, resource integration and technical support, we will continue to improve the overall technical implementation plan for intelligent assessment, monitoring and precise intervention of disability risk in the elderly.This will build a multi-level demonstration model for the prevention and control of elderly disability risk in cities, counties and townships in Zhejiang Province.The application effect of the elderly disability risk accurate assessment and intervention system was evaluated by indicators such as disability risk score, disability incidence, disability intervention compliance.

Interventions

OTHERRisk Assessment of Disability and Precision Intervention

Implement a digital platform for elderly disability risk intervention to conduct comprehensive, multi-scenario intelligent assessments, dynamic monitoring, and targeted interventions for disability risks.

Sponsors

Second Affiliated Hospital, School of Medicine, Zhejiang University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
Yes

Inclusion criteria

* Community-dwelling permanent residents aged ≥65 years; * Able to operate a smartphone independently or with assistance from a primary caregiver; * Clear consciousness with basic comprehension and communication abilities; * Voluntarily agree to participate in the study and provide informed consent.

Exclusion criteria

* Those who are unable to perform basic activities of daily living independently, or who have significant cognitive or communication impairments.

Design outcomes

Primary

MeasureTime frameDescription
SPPB(SHORT PHYSICAL PERFORMANCE BATTERY PROTOCOL)At baseline, 3 months after intervention, and 6 months after interventionthe range of score is 0-12, and the higher scores mean a better outcome.

Secondary

MeasureTime frameDescription
Incidence of disability6 months after interventionThe incidence of disability will be assessed using validated scales for Activities of Daily Living (ADL) and Instrumental Activities of Daily Living (IADL). Disability is defined as a new-onset, significant limitation in performing basic or complex everyday activities. The occurrence (i.e., the number of new cases) of disability will be determined at predefined study timepoints. The final outcome will be calculated as the proportion or rate of participants who develop disability during the study period, relative to the total number of participants.
Disability Risk ScoreAt baseline, 3 months after intervention, and 6 months after interventionThe Disability Risk Score is a continuous variable ranging from 0 to 1, calculated using a pre-validated prediction model. A higher score indicates a greater predicted risk of developing disability.
Intervention adherence3 months after intervention, and 6 months after interventionAdherence to the intervention protocol (e.g., exercise, dietary tasks) will be objectively monitored and recorded via a dedicated smartphone application. Participants are required to log or "check-in" within the app upon completion of each prescribed task. Adherence rates will be calculated as the percentage of completed tasks logged, relative to the total number of tasks assigned during the study period.

Countries

China

Contacts

CONTACTJingfen Jin, Master
zrjzkhl@zju.edu.cn+86 15888841161
PRINCIPAL_INVESTIGATORJingfen Jin, Master

The Second Affiliated Hospital of Medical College of Zhejiang University

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Jul 31, 2026