Head & Neck Cancer
Conditions
Keywords
Laryngeal dysplasia
Brief summary
Laryngeal dysplasia and progression to carcinoma: investigating genetic and immune alterations predictive of malignant transformation
Detailed description
Evaluate the immune population of TILs in LDy lesions with a high or low risk of malignant transformation. Analyze gene expression profiles in LDy lesions categorized by their risk of malignant progression.
Interventions
None listed
Sponsors
European Institute of Oncology
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 99 Years
Healthy volunteers
No
Inclusion criteria
* Histopathological diagnosis of laryngeal dysplasia. * Age \>18 years and informed consent.
Exclusion criteria
* Prior surgical, radiotherapeutic, or oncologic treatments for head and neck regions. * Congenital or acquired immunodeficiency disorders. * Synchronous malignancies. * Immunosuppressive therapy. * Age \<18 years or absence of research consent.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| differences in TILs counts | 2 years | detection of differences in TILs counts from Laryngeal dysplasia to progression to carcinoma |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Differences in TILs counts in LDy lesions | 2 years | Detection of Differences in TILs counts in LDy lesions categorized by their risk of malignant progression |
Countries
Italy
Contacts
CONTACTfrancesca lombardi
CONTACTMarta Tagliabue, MD
PRINCIPAL_INVESTIGATORMarta Tagliabue, MD
Istituto Europeo di Oncologia
Outcome results
None listed