Healthy
Conditions
Keywords
Swallow
Brief summary
The purpose of this study is to quantify the added benefit of visual biofeedback from High Resolution Pharyngeal Manometry (HRPM) for swallowing rehabilitation. Primary aims including assessing changes in swallowing biomechanics (pressure generation, timing) during swallow maneuvers with and without HRPM visual biofeedback. Secondary aim includes participant attitudes related to visual biofeedback and the experience of HRPM.
Interventions
OTHERSwallowing Maneuvers
Swallows will include 5 regular-effort saliva swallows (+/- visual biofeedback), 5 effortful saliva swallows (+/- visual biofeedback), 5 mendelsohn maneuver swallows (+/- visual biofeedback), and 5 masako or tongue hold maneuver swallows (+/- visual biofeedback).
DIAGNOSTIC_TESTHigh Resolution Pharyngeal Manometry (HRPM)
A diagnostic tool using a catheter with closely spaced sensors to measure pressures and timing within the pharynx and upper esophageal sphincter (UES) during swallowing
Sponsors
NYU Langone Health
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
1. Participants must be independent community dwelling adults. 2. Participants must be between the ages of 18-40 years old. 3. Willingness to consent and participate in the study procedures. 4. No reported dysphagia or difficulty swallowing evidenced by an EAT-10 Score \<3.
Exclusion criteria
1. Known structural or neurological causes of dysphagia (e.g., stroke, brain injury, or head/neck cancer). 2. Recent or remote history of swallowing therapy; familiarity with swallowing maneuvers from relevant coursework as applicable (i.e., speech language pathology students).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in pharyngeal contractile integral (PhCI) (mmHg) with and without visual biofeedback via HRPM | Baseline (without HRPM), with HRPM (up to 2 minutes) | Pharyngeal contractile integral, a product of mean pharyngeal contractile amplitude, length, and duration. Low PhCI (\< 100-150 mmHg·s·cm): Indicates hypo-contractility or weakness while High PhCI (\> 200-300+ mmHg·s·cm): Represents stronger contraction strength |
| Change in pharyngoesophageal Segment (PES) opening duration (ms) with and without visual biofeedback via HRPM | Baseline (without HRPM), with HRPM (up to 2 minutes) | Measures the duration of Upper Esophageal Sphincter (UES) opening in milliseconds. Short Duration (\<300ms) correlates with upper esophageal sphincter dysfunction, reduced laryngeal elevation, and poor pharyngeal contraction. |
| Change in PES pressure with visual biofeedback via HRPM with and without visual biofeedback via HRPM | Baseline (without HRPM), with HRPM (up to 2 minutes) | — |
Countries
United States
Contacts
CONTACTSonja Molfenter
CONTACTClaire Crossman
PRINCIPAL_INVESTIGATORSonja Molfenter
NYU Langone Health
Outcome results
None listed