Head & Neck Squamous Cell Carcinoma
Conditions
Keywords
Head and neck cancer, Adaptive radiotherapy, Online adaptive radiotherapy
Brief summary
Radiotherapy of head-neck cancer is associated with significant side effects. Using daily online adaptive radiotherapy to account for the changing anatomy, radiation to organs at risk can be lowered. We will investigate whether this is feasible and associated with a reduction in the risk of toxicity.
Interventions
RADIATIONDaily online adaptive radiotherapy
The patients will undergo daily online adaptive re-optimisation of the radiotherapy treatment plan following daily recontouring.
Sponsors
Rigshospitalet, Denmark
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients with histologically proven squamous cell carcinoma of the pharynx or larynx planned for primary radiotherapy with curative intent No current or earlier malignancies, which may influence treatment, evaluation or outcome of the head-neck cancer Informed consent as required by law The patient cannot participate in conflicting protocols Stage I-IV (excluding T1-T2N0 carcinoma of the glottic larynx) ECOG/WHO performance status 0-2
Exclusion criteria
Patient with cancers of the glottic larynx (stage I/II), skull base, sino-nasal area and unknown primary tumor. Inability to attend full course of radiotherapy or follow-up visits in the outpatient clinic Distant metastasis Previous radiotherapy of the head and neck Previous surgery for the primary cancer with curative intent \-
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Risk of dysphagia and xerostomia six months post-treatment assesed by normal-tissue complication probability (NTCP) models | 6 months after treatment |
Countries
Denmark
Contacts
CONTACTJeppe Friborg, MD, PhD
CONTACTAnne Lindegaard, MD
Outcome results
None listed