Dexmedetomidine as an Adjuvant During Dural Puncture Epidural

The Effect of Different Doses of Dexmedetomidine as an Adjuvant to Bupivacaine for Parturients Having Dural Puncture Epidural Technique to Elaborate Labor Pain

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07506044

Enrollment

140

Registered

2026-04-01

Start date

2026-05-30

Completion date

2026-10-30

Last updated

2026-08-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Total Dose of Bupivacaine Administered During Labor

Keywords

Labour, Epidural, Dexmedetomidine

Brief summary

The study aimed to determine the effects of using varied doses of DEX on the concentration of bupivacaine injected for epidural labor analgesia, and to assess the benefits of the dural puncture epidural.

Detailed description

The primary efficacy point is the total dose of bupivacaine administered during labor. The secondary endpoints include the VAS pain scores, number of administered additional doses, incidence of motor block, delivery type (spontaneous vaginal or cesarean), maternal satisfaction, and complications such as hypotension, fetal bradycardia, and epidural-related maternal fever.

Interventions

DEVICEEpidural Catheter with bupivacaine

epidural injection of plain Bup

DEVICEEpidural with dural puncture

the dura is punctured by a 26-G spinal needle using the needle-through-needle technique, and is withdrawn after confirmation of free-flowing cerebrospinal fluid,

DRUGDexmedetomidine 0.4 added

Dexmedetomidine 0.4 added

DRUGDexmedetomidine 0.6 added

Dexmedetomidine 0.6 added

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Caregiver)

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 40 Years

Healthy volunteers

Inclusion criteria

* Women who attend the Emergency Department in labor, with cervical dilation of 3-5 cm, * normally presented singleton fetus, intact fetal membranes, and who are free of

Design outcomes

Primary

Measure	Time frame	Description
Total dose of bupivacaine	From the induction of epidural to the delivery of the fetus	Total dose of bupivacaine administered

Secondary

Measure	Time frame	Description
Labor pain	Before initiation of epidural ,10 ,30,45,60 min after initiation then every 1hour till the delivery of the fetus	Labour pain measured by Visual analogue
Motor block	Before initiation of epidural ,10 ,30,45,60 min after initiation then every 1hour till the delivery of the fetus	Motor block measured by bromage scsle
Delivery type	At time of fetus delivery	Delivery type spontaneous or instrument
Maternal satisfaction	Preoperative,2nd stage of labour, third stage of labour and immediately after delivery, 2 hours after delivery,4 hours after delivery,12 hours after delivery	Satisfied or not
Complications	Preoperative,2nd stage of labour, third stage of labour and immediately after delivery, 2 hours after delivery,4 hours after delivery,12 hours after delivery	Any complications detected

Countries

Egypt

Contacts

CONTACTRabab Habeeb, MD

rabab_habeeb@med.menofia.edu.eg+201001970973

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Aug 14, 2026