GLP - 1
Conditions
Keywords
GLP-1, Food choice, Cravings, Food cue reactivity
Brief summary
The purpose of this randomized control trial is to compare how food cravings, food selection, and food consumption change in response to frequent food advertisements compared to non-food advertisements in adults taking GLP-1 (weight loss) medications. The primary question we aim to answer is: do GLP-1 medications reduce an individual's vulnerability to external triggers that drive food cravings and consumption? Participants will: * report daily food consumption for a total of 10 days, * receive eight daily prompts to view food or non-food related advertisements, and respond to a short 9-question survey for 7 days, * answer several questionnaires, * and complete two in-person visits to complete a virtual reality food selection task.
Interventions
BEHAVIORALFood advertisements
Videos and images of food and beverage advertisements from popular brands and/or restaurants
BEHAVIORALTech advertisements
Video and photo advertisements of popular tech tools
Sponsors
Penn State University
Penn State Health
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* Adults (18+) with overweight or obesity (BMI \>25 kg/m2) * On an injectable form of tirzepatide GLP-1 medication at a minimum dose of 7.5 mg, taking it as prescribed by their doctor * Not currently taking an incretin-based medication at baseline other than the GLP-1 medication * Fluent in English
Exclusion criteria
* Do not have consistent access to a smart phone that can access the study software * Diagnosed with cognitive or physical disability or epilepsy * Adults taking a compound GLP-1
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Mean food cue reactivity scores in the afternoon | 7-day period of all afternoon survey responses | Average scores of craving levels for each group following afternoon advertisement viewing sessions |
| Mean food cue reactivity scores in the morning | 7-day period of all morning survey responses | Average scores of craving levels for each group following morning advertisement viewing sessions |
| Mean food cue reactivity scores in the evening | 7-day period of all evening survey responses | Average scores of craving levels for each group following evening advertisement viewing sessions |
| Mean food cue reactivity scores overall | 7-day period of all survey responses | Average scores of craving levels for each group over all viewing sessions |
| Energy density of consumed foods | 7 days | The energy density profile of foods consumed each day |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline in energy density of foods selected in the virtual buffet | Baseline and 7 days | — |
| Changes in food noise since being on medication questionnaire | Baseline | Questionnaire assessing various aspects of food noise at present compared to before the medication |
| Changes in reasons for purchasing foods questionnaire | Baseline | A questionnaire that assesses how five factors impact purchasing choices, and how the main factors have changed between prior to starting the medication and after. |
| Individual Food Cue Responsiveness--Trait | Baseline | — |
| Change in brand familiarity, liking, and/or craving | Baseline and 7 days | A questionnaire that measures the familiarity, liking, and craving of each brand the participant will be exposed to (baseline) or has been exposed to (after intervention). |
Outcome results
None listed