Peri-implantitis
Conditions
Keywords
peri-implantitis, antiseptic solution, air-water polishing
Brief summary
The goal of this clinical study is to compare the effectiveness of different methods for decontaminating dental implant surfaces in the treatment of peri-implantitis. The main question it aims to answer is: Which combination of an antiseptic solution and an air-polishing powder is most effective for the non-surgical treatment of peri-implantitis? Researchers will compare three different treatment combinations (Miramistin with sodium bicarbonate, chlorhexidine with erythritol, and Octenisept with glycine) in patients diagnosed with peri-implantitis. Participants will receive the combined treatment at intervals of 7-10 days for one month. The study will assess changes in probing depth, bleeding, and bone loss at 1 and 2.5 months after treatment to determine the most effective and balanced approach for preserving implant surfaces and promoting tissue healing.
Detailed description
This is a prospective, interventional study involving 48 patients diagnosed with peri-implantitis. Groups: Participants were allocated into three groups (n=16 per group) to receive one of three treatment combinations. Group 1: Treatment with Miramistin solution (0.01%) and air-polishing with sodium bicarbonate powder. Group 2: Treatment with Chlorhexidine solution (0.05%) and air-polishing with erythritol powder. Group 3: Treatment with Octenisept solution and air-polishing with glycine powder. Intervention: Each patient received the assigned combination treatment at intervals of 7-10 days over one month. Outcome Measures: Clinical parameters were assessed at baseline, 1 month, and 2.5 months after the start of treatment: Primary Clinical Outcomes: Changes in probing depth (PD) and bleeding on probing (BOP). Secondary Clinical Outcomes: Changes in plaque index (PLI), gingival index (GI), presence of suppuration, and radiographic bone loss (assessed via periapical radiographs and cone-beam computed tomography (CBCT)). The need for subsequent surgical intervention was also recorded.
Interventions
DRUGMiramistin
Antiseptic solution (0.01%) used for irrigation of the peri-implant pocket.
PROCEDURESodium Bicarbonate Powder
Abrasive powder used for air-polishing debridement of the implant surface at a 45-degree angle
DRUGChlorhexidine
Antiseptic solution (0.05%) used for irrigation of the peri-implant pocket.
PROCEDUREErythritol Powder
Abrasive powder used for air-polishing debridement of the implant surface at a 45-degree angle.
DRUGOctenisept
Antiseptic solution used for irrigation of the peri-implant pocket.
PROCEDUREGlycine Powder
Abrasive powder used for air-polishing debridement of the implant surface at a 45-degree angle.
Sponsors
Research Centre for Medical Genetics, Russian Federation
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
21 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Age between 21 and 75 years * Presence of at least one dental implant * Diagnosis of peri-implantitis defined as probing depth ≥ 6 mm and radiographic bone loss ≥ 3 mm apical to the most coronal portion of the intraosseous part of the implant * Ability to attend follow-up appointments for up to 3 months * Willingness to participate and provide written informed consent
Exclusion criteria
* Presence of systemic diseases in a decompensated stage (e.g., uncontrolled diabetes mellitus, severe cardiovascular disease, psychotic disorders, active oncological disease) * Current or prior use of immunosuppressive drugs, bisphosphonates, high-dose corticosteroids, antipsychotics, or other medications known to negatively affect peri-implant tissue regeneration and healing * Pregnancy or lactation * Unwillingness or inability to comply with study procedures * Peri-implantitis requiring immediate surgical intervention or implant removal at baseline
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Probing Depth | Baseline, 1 month, and 2.5 months after start of treatment | Probing depth measured in millimeters using a graduated periodontal probe (UNC-15) at six sites per implant: mesiobuccal, buccal, distobuccal, mesiolingual, lingual, and distolingual. The mean probing depth per implant is calculated. A reduction in probing depth indicates treatment success. |
| Bleeding on Probing | Baseline, 1 month, and 2.5 months after start of treatment | Presence or absence of bleeding within 30 seconds after gentle probing at six sites per implant. The percentage of sites showing bleeding per implant is recorded. A decrease in bleeding on probing indicates improvement in peri-implant soft tissue health. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Plaque Index | Baseline, 1 month, and 2.5 months after start of treatment | Plaque accumulation assessed using the Silness-Löe Plaque Index (0-3 scale) at six sites per implant. Mean PLI is calculated per implant. |
| Gingival Index | Baseline, 1 month, and 2.5 months after start of treatment | Gingival inflammation assessed using the Löe-Silness Gingival Index (0-3 scale) at six sites per implant. Mean GI is calculated per implant. |
| Radiographic Bone Loss | Baseline and 2.5 months after start of treatment | Vertical bone loss measured in millimeters from a fixed reference point (e.g., implant shoulder) to the most coronal bone-to-implant contact, assessed on periapical radiographs and cone-beam computed tomography (CBCT). |
| Need for Surgical Intervention | From start of treatment through 2.5 months | Number and severity of adverse events related to the treatment, including post-operative pain, soft tissue irritation, allergic reactions, or any unexpected events. |
| Suppuration | Baseline, 1 month, and 2.5 months after start of treatment | Presence or absence of suppuration (purulent exudate) after gentle probing. Reported as the percentage of sites with suppuration per implant. |
Countries
Russia
Outcome results
None listed