Polycystic Ovary Syndrome (PCOS)
Conditions
Keywords
PCOS, Fertility, parental project, pregnancy, hormonal factors, metabolic factors
Brief summary
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women of reproductive age and affects approximately 10% of women worldwide. The diagnosis is based on the Rotterdam criteria established in 2003 and updated in the latest recommendations from the European Society of Human Reproduction (ESHRE) in 2023. The diagnosis of PCOS is based on the presence of 2 of the following 3 criteria: 1. Oligo-anovulation 2. Clinical and/or biological hyperandrogenism 3. Polycystic ovary morphology (PCOM) on imaging It is also the leading cause of anovulatory infertility, with a 15-fold increased risk of infertility. It is therefore a major cause of anovulatory infertility, but its pathophysiological mechanisms remain complex and multifactorial, involving interactions between genetic, metabolic, hormonal, and environmental factors. Prior to embarking on a fertility treatment plan, it is essential to better understand how these various factors influence ovarian function and reproductive capacity in patients with PCOS. Identifying and characterizing factors associated with fertility-such as hormonal profiles, insulin sensitivity, and metabolic markers-could help better predict future fertility and optimize personalized care and fertility outcomes. The aim of this study is therefore to identify modifiable factors influencing the fertility of PCOS patients phenotyped at La Pitié-Salpêtrière hospital.
Interventions
OTHERQuestionnaires
Questionnaires about fertility and potential pregnancies
Sponsors
Assistance Publique - Hôpitaux de Paris
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
- PCOS group: * Aged between 18 and 45 years old * Female with a diagnosis of PCOS according to ESHRE criteria * Previouslu enrolled in METABOPK research Inclusion Criteria- Control group * Aged between 18 and 45 years old * Female with normal metabolic and hormonal profiles * Previouslu enrolled in METABOPK research
Exclusion criteria
* A prior diagnosis of type 1 or type 2 diabetes * A diagnosis of non-classical adrenal block * Use of hormonal therapy, oral antidiabetic medication, lipid-lowering medication, antihypertensive medication, corticosteroids, or spironolactone * Menopause or current pregnancy * Lack of data on BMI, insulin levels, and fasting blood glucose * Patients who do not speak French * Patients under legal guardianship, conservatorship, or curatorship
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Description of the mode of conception | Through study completion, an average of 1 year | Description of the mode of conception: spontaneous or induced; if induced, by which ART technique or following which treatment to improve PCOS symptoms (inositol, GLP-1 analog, metformin, lifestyle and dietary changes, etc.). These informations will be colected from medical records and frome the specific questionnaire. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Description of the treatment protocols for infertility | Through study completion, an average of 1 year | Description of the treatment protocols for infertility among women in the cohort, if applicable: The description of infertility will be based on patient reports and treatment records |
| Description of obstetric complications | Through study completion, an average of 1 year | Description of obstetric complications: ectopic pregnancy, miscarriage, intrauterine fetal death, intrauterine growth restriction (IUGR), gestational diabetes, hypertension, preeclampsia, HELLP syndrome, intrahepatic cholestasis of pregnancy, gestational age at delivery, spontaneous or induced labor, birth weight, breastfeeding possible if desired: The description of obstetric complications will be based on data from the specific questionnaire and from pregnancy and delivery follow-up reports. |
| Identification of hormonal and metabolic factors associated with infertility and obstetric complications | Through study completion, an average of 1 year | Identify hormonal and metabolic factors associated with infertility and obstetric complications early on so that appropriate measures can be taken in preparation for starting a family |
Countries
France
Contacts
CONTACTAnne BACHELOT, MD, PhD
PRINCIPAL_INVESTIGATORAnne BACHELOT, MD-PhD
Assistance Publique - Hôpitaux de Paris
Outcome results
None listed