Renal Cell Carcinoma (RCC), Renal Function Abnormal
Conditions
Keywords
Renal Function Abnormal, Acute kidney injury, Partial nephrectomy, Ischemic preconditioning
Brief summary
It is demonstrated that remote ischemic preconditioning can alleviate the degree of acute renal injury on the operated side in patients undergoing partial nephrectomy.
Detailed description
The study cohort was randomly divided into two groups. One group received remote ischemic preconditioning one day before partial nephrectomy, while the other group underwent partial nephrectomy directly. The degree of acute renal injury on the operated side was compared between the two groups
Interventions
PROCEDUREIschemic preconditioning
One day before the surgery, use a sphygmomanometer to apply pressure to the patient's upper limb to 200mmHg for 5 minutes, then reduce the pressure to 0mmHg for 5 minutes, repeating this process for a total of 3 cycles. On the second day, perform a routine partial nephrectomy
PROCEDURENO ischemic preconditioning
Routine partial nephrectomy
Sponsors
Sun Yat-sen University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
The study cohort was randomly divided into two groups. One group received remote ischemic preconditioning one day before partial nephrectomy, while the other group underwent partial nephrectomy directly. The degree of acute renal injury on the operated side was compared between the two groups
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Patients who are scheduled to undergo partial nephrectomy, with no specific surgical procedure limitation, including laparoscopic surgery, robot-assisted surgery, and open surgery * Aged 18 to 80 * Possess good organ function status: sufficient organ function (based on the normal values of the clinical trial center) 1. Blood routine test: WBC≥3.5×10\^9/L, absolute neutrophil count ≥1.5×10\^9/L, PLT≥75.0×10\^9/L, HGB≥80g/L; 2. Liver function: Total bilirubin ≤1.5×upper limit of normal (ULN), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤2.5×ULN;
Exclusion criteria
* The anesthesiologist assesses that the patient cannot tolerate general anesthesia surgery * Individuals with severe cardiovascular and cerebrovascular diseases, uncontrolled hypertension, and diabetes * Estimated glomerular filtration rate (eGFR) \< 30 ml/min/1.73m² * Horseshoe kidney * Solitary kidney * Pregnant women
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| AIRD spectrum score based on the patient's preoperative creatinine level and postoperative peak creatinine level | 2 weeks after partial nephrectomy | The AIRD spectrum score was defined as: (observed peak SCr - SCr ideal-peak)/(SCr worstcase-peak - SCr ideal-peak） The range of this indicator should be between 0 and 1, with 0 and 1 representing two extreme situations. 0 indicates that the kidney on the operated side is completely undamaged, while 1 indicates that the kidney on the operated side has completely lost its function. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Recovery from ischemia based on the changes in creatinine levels before and after the partial nephrectomy and volume retention rate after the partial nephrectomy | 3 month after surgery | Recovery from ischemia = (%GFR saved)/(%parenchymal mass preserved) |
Countries
China
Contacts
CONTACTFangjian Zhou, professor
PRINCIPAL_INVESTIGATORFangjian Zhou, professor
Sun Yat-sen University Cancer Center (SYSUCC)
Outcome results
None listed