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Effects of Different Caffeine Forms on Aerobic and Anaerobic Exercise Performance

Comparative Acute Effects of Caffeine Delivery Forms (Capsule, Chewing Gum, Mouth Rinse) on Aerobic Capacity and Wingate Anaerobic Performance Outcomes in Recreational Male Athletes: A Randomized Counterbalanced Crossover Trial

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07497685
Enrollment
14
Registered
2026-03-27
Start date
2026-04-20
Completion date
2026-06-30
Last updated
2026-08-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Exercise Performance, Physical Performance

Keywords

Caffeine, Aerobic Performance, Anaerobic Performance, VO2max, Wingate Test, Ergogenic Aid, Exercise Physiology

Brief summary

This study investigated the effects of different caffeine delivery forms on aerobic and anaerobic exercise performance in healthy adults. Participants completed experimental trials involving caffeine capsule ingestion, caffeine gum chewing, and caffeine mouth rinse conditions. Aerobic performance was assessed using maximal oxygen uptake (VO2max), and anaerobic performance was evaluated using the Wingate anaerobic test. The study used a randomized crossover design where each participant completed all experimental conditions.

Detailed description

Caffeine is widely used as an ergogenic aid to enhance athletic performance. Different forms of caffeine administration such as capsules, chewing gum, and mouth rinses may produce different physiological responses due to differences in absorption rate and oral receptor stimulation. However, limited research has directly compared these delivery methods within the same participants. This randomized crossover study aimed to compare the effects of caffeine capsule ingestion, caffeine gum chewing, and caffeine mouth rinse on aerobic and anaerobic exercise performance. Fourteen healthy adults participated in the study and completed experimental trials under each caffeine condition. Aerobic performance was measured using maximal oxygen uptake (VO2max), while anaerobic performance was assessed using the Wingate anaerobic test. The results of this study may help clarify the effectiveness of different caffeine delivery forms for improving exercise performance.

Interventions

OTHERComparative Acute Effects of Caffeine Delivery Forms (Capsule, Chewing Gum, Mouth Rinse) on Aerobic Capacity and Wingate Anaerobic Performance Outcomes in Recreational Male Athletes: A Randomized Coun

This study evaluates the acute effects of three distinct caffeine delivery methods compared to a placebo, using a standardized total dose of 300 mg of caffeine across all active interventions. The study is a randomized, counterbalanced crossover trial involving 14 recreational male athletes. The interventions are distinguished by their specific absorption kinetics and ecologically valid administration timings

Sponsors

University of Gaziantep
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER
Masking
NONE

Intervention model description

Participants completed all experimental conditions in a randomized crossover order. Each participant performed exercise tests under three different caffeine administration conditions (caffeine capsule, caffeine gum, and caffeine mouth rinse). The order of the conditions was randomized, and adequate washout periods were provided between trials to minimize carryover effects.

Eligibility

Sex/Gender
MALE
Age
18 Years to 25 Years
Healthy volunteers
Yes

Inclusion criteria

* Healthy male recreational athletes aged 18-25 years. * At least 2 years of regular training history (3-4 sessions per week). * Non-smoker.No diagnosed chronic disease. * No current musculoskeletal injury. * Willingness to abstain from caffeine consumption for 48 hours before each test session. * Willingness to avoid strenuous exercise for 48 hours before each test session.

Exclusion criteria

* Known allergy or sensitivity to caffeine. * Use of any performance-enhancing supplements during the study period. * Failure to comply with the standardized nutritional requirements before testing. * Failure to comply with the standardized sleep requirements before testing. * Inability to complete all experimental conditions (Capsule, Gum, Rinse, and Placebo).

Design outcomes

Primary

MeasureTime frameDescription
Anaerobic Average PowerMeasured after each 48-hour washout period following the specific caffeine or placebo intervention.The mean power output maintained over the duration of a 30-second Wingate Anaerobic Test
Aerobic Capacity (VO2max)Measured after each 48-hour washout period following the specific caffeine or placebo interventionDescription: Estimated maximal oxygen uptake calculated via the 20-meter shuttle run test (Beep Test).Metric: Milliliters per kilogram per minute (ml/kg/min)

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Aug 21, 2026