Cardiovascular Acoustics for Early Disease Detection

ACOUTECT: Cardiovascular Acoustics for Early Disease Detection

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07496775

Acronym

ACOUTECT

Enrollment

500

Registered

2026-03-27

Start date

2026-05-01

Completion date

2029-12-31

Last updated

2026-04-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary Artery Disease, Valvular Heart Disease

Keywords

coronary artery disease, valvular heart disease, ischemic heart disease, cardiovascular acoustics, heart sounds, cardiac auscultation

Brief summary

There are many types of heart disease. Two of the most common causes are narrowings within the blood vessels that supply the heart (known as coronary artery disease), or valves within the heart becoming narrowed (stenosed) or leaky (regurgitation), known as heart valve disease. There are two main types of imaging used to test for these conditions. Coronary artery disease can be diagnosed by taking X-ray pictures of a dye when injected into the blood vessels. In some cases the dye is injected into the veins and a CT scanner is used (CT coronary angiography), in others the dye is injected via a tube placed in the artery (invasive coronary angiography). Valvular heart disease is normally diagnosed using an echocardiogram (ultrasound of the heart). In this study the investigators are looking for subtle changes in the sounds that come from the heart, which may allow heart disease to be detected earlier. The investigators are using a novel device, similar to a digital stethoscope, that has excellent sensitivity for heart sounds. Ultimately this may be used in community settings including GP surgeries, in this study the investigators are collecting sounds from patients undergoing routine scans as part of their workup for heart disease.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Participants aged ≥18 years * Able to provide written, informed consent * Has undergone angiography in the previous 6 months and scheduled to undergo transthoracic echocardiography, or has undergone transthoracic echocardiography in the previous 6 months and scheduled to undergo angiography, or is scheduled to undergo transthoracic echocardiography and angiography within 6 months. * Angiography and echocardiography performed within Cambridge University Hospitals NHS Foundation Trust.

Exclusion criteria

* Haemodynamic instability * STEMI or high risk NSTEMI * Anginal symptoms at rest * Heart failure symptoms with NYHA 4 * Cardiovascular related admission or event occurring between imaging studies * Uncontrolled symptomatic arrhythmia * Acute pulmonary embolism * Acute aortic dissection * Previous valve intervention * Suspected endocarditis

Design outcomes

Primary

Measure	Time frame	Description
Discriminant score	Investigations to be performed within six (6) months of one another.	A discriminant score (minimum 0, maximum 1) for each of coronary artery disease and valvular heart disease will be generated by analysis of the phonographs.

Contacts

CONTACTStephen Kelleher

cuh.research@nhs.net01223 217418

PRINCIPAL_INVESTIGATORJames HF Rudd, PhD FRCP

University of Cambridge

STUDY_DIRECTORJacob B Brubert, PhD MRCP

Cambridge University NHS Foundation Trust

Outcome results