Acute Ischemic Cerebrovascular Disease, Aphasia, Acquired, Aphasia Following Cerebral Infarction, Post Stroke Aphasia
Conditions
Keywords
Transcranial Direct Current Stimulation, tDCS, Acute Ischemic Cerebrovascular Disease, Post stroke aphasia, Aphasia Following Cerebral Infarction
Brief summary
The use of transcranial direct current stimulation (tDCS) for the management of deficits developed in stroke is a relatively new type of management option. Many of the studies performed using tDCS have focused on improvements noted in hemiplegia as compared to aphasia, which is an equally disabling outcome of strokes. The results of these studies have not been conclusive and concordant with each other. In aphasia management, the majority of the studies have focused on chronic strokes. Since the use of tDCS is relatively new, the studies have not focused on a particular type of deficit or stroke. Very few studies have focused on the impact of solely using tDCS. Very few studies have focused on acute to subacute strokes. The results of the studies have, nevertheless, been encouraging. Improvements in aspects of language tested after a single session of tDCS are short-lived. There is an unmet need to probe the utility of repetitive tDCS on aspects of language function in patients who are aphasic due to acute stroke. There is also a paucity of data in the Indian scenario regarding the same.
Interventions
DEVICETranscranial Direct Current Stimulation
Anodal tDCS
Sponsors
Dr. Ram Manohar Lohia Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Aphasic patients with left middle cerebral artery territory Acute Ischemic Stroke * Patients between 18-65 years of age. * Within 5 days of onset of stroke.
Exclusion criteria
* Patients with malignant Middle Cerebral Artery territory infarcts and previous clinical history of cerebral hemisphere stroke. * Patients with history of previous brain surgery or skull defect due to surgery e.g. craniectomy. * Patients with epilepsy. * Patients with history of significant head trauma in the last 1 month. * Patients with documented history of major depression prior to stroke. * Patients with alcohol/drug abuse in the past 6 months. * Patients with prior significant cognitive impairment. * Pacemaker in situ, cochlear implant in situ. * Pregnancy.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Primary Outcome: Difference of change in Accuracy between Anodal tDCS group and Sham tDCS group at 5 days | at 5 days after tDCS | Accuracy is defined as the number of words spoken without the help of a semantic or phonemic cue on the ICMR Picture Naming Test |
| Co-Primary outcome: Difference of change in Reaction Time between Anodal tDCS group and Sham tDCS group at 5 days | at 5 days after tDCS | Reaction times were documented in milliseconds. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Difference of change in Correct Response between Anodal tDCS group and Sham tDCS group at 5 days | at 5 days after tDCS | Correct Response is defined as the total number of words spoken, with or without the help of either a semantic or a phonemic cue on the ICMR Picture Naming Test. |
| Difference of change in PNT Score between Anodal tDCS group and Sham tDCS group at 5 days | at 5 days after tDCS | PNT scores are recorded as per the guidelines of the ICMR Picture Naming Test |
| Difference of change in Accuracy between Anodal tDCS group and Sham tDCS group at 4 weeks | at 4 weeks after tDCS | Accuracy is defined as the number of words spoken without the help of a semantic or phonemic cue on the ICMR Picture Naming Test |
| Difference of change in Reaction Time between Anodal tDCS group and Sham tDCS group at 4 weeks | at 4 weeks after tDCS | Reaction times were documented in milliseconds. |
| Difference of change in Correct Response between Anodal tDCS group and Sham tDCS group at 4 weeks | at 4 weeks after tDCS | Correct Response is defined as the total number of words spoken, with or without the help of either a semantic or a phonemic cue on the ICMR Picture Naming Test. |
| Difference of change in PNT Score between Anodal tDCS group and Sham tDCS group at 4 weeks | at 4 weeks after tDCS | PNT scores are recorded as per the guidelines of the ICMR Picture Naming Test. |
Countries
India
Contacts
CONTACTAshish Kumar Duggal, Doctor (Professor)
CONTACTDevavrata Sahu, Doctor
PRINCIPAL_INVESTIGATORAshish Kumar Duggal, DM (Neurology)
Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital, New Delhi
Outcome results
None listed