Acute Brain Injuries, Mechanical Ventilation
Conditions
Brief summary
Invasive mechanical ventilation (IMV) is a life-saving supportive therapy for patients with acute brain injury, which accounted for nearly one-fifth of all mechanically ventilated patients in the intensive care unit (ICU). However, prolonged exposure to IMV is consistently associated with an increased risk of ventilator-related complications and adverse outcomes. Accordingly, alongside the initiation of IMV, timely and safe liberation from ventilator should be considered. Nevertheless, data detailing the weaning process and its associated outcomes in mechanically ventilated patients with ABI remain scarce. To address this gap, the investigators conducted an observational study aimed at characterizing the ventilator weaning process and outcomes in patients with ABI receiving IMV, using the modified WIND classification.
Interventions
None listed
Sponsors
Southeast University, China
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients with ABI * ≥ 18 years old * underwent IMV for at least 24 hours
Exclusion criteria
* already tracheostomized * concurrent of cervical spinal cord injury * pregnant or lactation * withdraw of life-sustaining treatment within the first 24 hours of ICU admission
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| weaning outcome | day 90 | The primary endpoint was the weaning outcome according to the modified WIND classification |
Countries
China
Outcome results
None listed