Sleep Disorder Insomnia Chronic
Conditions
Keywords
sleep disorder, Heart-brain axis, magnetoencephalography, magnetocardiography
Brief summary
The main purpose of the study is to explore the mechanisms by which mood and sleep disorders interact. The exploratory aim of this study is to discover the relationship between ECG/MCG and EEG/MEG characteristics and mood and sleep disorders and to discover the correlation between cardio-brain monitoring and to explore the mechanisms by which mood and sleep disorders influence each other.
Interventions
OTHERelectrocardiographic/magnetic and electroencephalographic/magnetic monitoring data
First, a 5-minute baseline measurement is performed, and then, 5 different musical stimuli are played in turn, each lasting for 3 minutes. After each music is played, a 1-minute break is arranged. After the last musical stimulation, a 5-minute end measurement is performed to record the final physiological indicators.
DIAGNOSTIC_TESTambulatory electrocardiogram
Subjects wore a dynamic ECG for 24 hours before the start of the tria
OTHERGeneral clinical information
General situation collection: Detailed baseline data collection for all participants, including basic demographic characteristics such as age, gender, education level, health status, sleep and lifestyle
OTHERscale assessment
Measure Pittsburgh Sleep Quality Index (PSQI), Insomnia Severity Index (ISI), Montreal Cognitive Assessment Scale (MoCA), Simple Intelligent Mental State Check Scale (MMSE), Hamilton Anxiety Scale (HAMA), Hamilton Depression Scale (HAMD), Epworth Drowsiness Scale (ESS), SF-36 Quality of Life Tables and other related scale information
Sponsors
Qilu Hospital of Shandong University
Study design
Observational model
OTHER
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
1.Normal health group2.Mood disorders with insomnia group3.Mood disorders without insomnia group4.Primary insomnia group
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| High-Frequency Power of Heart Rate Variability | Baseline (5 minutes); during each 3-minute musical stimulus; post-stimulus baseline (5 minutes) | High-frequency power component of heart rate variability (HF-HRV) derived from electrocardiographic spectral analysis, reflecting parasympathetic (vagal) activity. HF-HRV is reported in milliseconds squared (ms²). |
| Low-Frequency Power of Heart Rate Variability | 5-minute baseline; during each 3-minute musical stimulus; 5-minute post-stimulus baseline | Low-frequency power component of heart rate variability derived from electrocardiographic spectral analysis during baseline and musical stimulation periods, reflecting combined sympathetic and parasympathetic modulation, reported in milliseconds squared (ms²). |
| Magnetocardiographic Frequency-Domain Parameters | A 5-minute baseline measurement; 5 different musical stimuli, each lasting 3 minutes; a 5-minute baseline measurement | Magnetocardiographic Frequency-Domain Parameters - measured in Tesla squared per Hertz (T²/Hz) to analyze spectral properties of cardiac magnetic signals, including power spectral density and energy distribution across frequency bands. |
| Electroencephalographic Event-Related Potential Components | A 5-minute baseline measurement; responses during five different musical stimuli, each lasting 3 minutes; a second 5-minute baseline measurement | Electroencephalographic Event-Related Potential Components - measured in microvolts (µV) to quantify electrical brain response amplitudes and latencies in milliseconds during cognitive and emotional processing tasks. |
| Electroencephalographic Oscillatory Power | A 5-minute baseline measurement; responses during five different musical stimuli, each lasting 3 minutes; a second 5-minute baseline measurement | Electroencephalographic Oscillatory Power - measured in decibels (dB) to assess rhythmic neural activity power within specific frequency bands including alpha, beta, theta, gamma, and delta oscillations. |
| Magnetoencephalographic Event-Related Field Components | A 5-minute baseline measurement; responses during five different musical stimuli, each lasting 3 minutes; a second 5-minute baseline measurement | Magnetoencephalographic Event-Related Field Components - measured in Tesla (T) to evaluate magnetic brain response amplitudes and latencies in milliseconds during cognitive and emotional processing tasks. |
| Magnetoencephalographic Oscillatory Power | A 5-minute baseline measurement; responses during five different musical stimuli, each lasting 3 minutes; a second 5-minute baseline measurement | Magnetoencephalographic Oscillatory Power - measured in decibels (dB) to quantify magnetic field oscillations power within specific frequency bands including alpha, beta, theta, gamma, and delta rhythms. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Demographic Characteristics | Before the experiment begins | A self-administered General Information Questionnaire was used to collect baseline demographic data, with age measured in years, sex categorized as male or female, and educational level quantified as the total number of years of formal education completed. |
| Pittsburgh Sleep Quality Index (PSQI) | Before the experiment begins | Pittsburgh Sleep Quality Index (PSQI) - measured in scores to assess sleep quality, with scores ≥ 7 indicating clinically significant insomnia and higher scores representing poorer sleep quality. |
| Hamilton Anxiety Rating Scale (HAMA) | Before the experiment begins | Hamilton Anxiety Rating Scale (HAMA) - measured in scores to evaluate anxiety severity, with scores ≥ 14 suggesting probable anxiety symptoms and higher scores indicating more severe anxiety. |
| Hamilton Depression Rating Scale (HAMD) | Before the experiment begins | Hamilton Depression Rating Scale (HAMD) - measured in scores to assess depression severity, with scores ≥ 17 (or ≥ 8 for the 8-item version) suggesting probable depressive symptoms and higher scores representing more severe depression. |
| Montreal Cognitive Assessment (MoCA) | Before the experiment begins | Montreal Cognitive Assessment (MoCA) - measured in scores to evaluate cognitive function across multiple domains, with higher scores indicating better cognitive performance. |
| Mini-Mental State Examination (MMSE) | Before the experiment begins | Mini-Mental State Examination (MMSE) - measured in scores to assess global cognitive function, with higher scores representing better cognitive performance. |
| Magnetocardiographic Signal Amplitude | 5-minute baseline; during each 3-minute musical stimulus; 5-minute post-stimulus baseline | Peak magnetic signal amplitude of cardiac activity measured using magnetocardiography during baseline and musical stimulation periods, reported in Tesla (T). |
| Standard Deviation of Normal-to-Normal Intervals | 5-minute baseline; during each 3-minute musical stimulus; 5-minute post-stimulus baseline | Standard deviation of normal-to-normal (NN) R-R intervals derived from electrocardiographic recordings as a time-domain measure of overall heart rate variability, reported in milliseconds (ms). |
| Magnetocardiographic Signal Duration | 5-minute baseline; during each 3-minute musical stimulus; 5-minute post-stimulus baseline | Duration of magnetocardiographic cardiac waveform measured during baseline and musical stimulation periods, reported in milliseconds (ms). |
| Magnetocardiographic Waveform Field Strength | 5-minute baseline; during each 3-minute musical stimulus; 5-minute post-stimulus baseline | Magnetic field strength of specific cardiac waveform components measured during baseline and musical stimulation periods, reported in Tesla (T). |
Countries
China
Outcome results
None listed