Parkinson Disease (PD)
Conditions
Keywords
Electroencephalography, Executive function, Obstacle crossing
Brief summary
People with Parkinson's disease (PD) may have difficulty stopping or changing their movements, especially when walking around obstacles. The goal of this observational study is to learn if a specific cognitive function, called inhibitory control (the ability to stop or control actions) is associated with gait adaptability in people with Parkinson's disease. Gait adaptability means the ability to adjust how a person walks in response to changes in the environment, such as stepping over obstacles. The main questions the study aims to answer are: * If brain activation related to inhibitory control, measured by EEG, is associated with gait adaptability during obstacle crossing in people with Parkinson's disease? * If behavioral inhibitory control is associated with gait adaptability during obstacle crossing in people with Parkinson's disease? Participants take part in one study visit. During this visit, participants complete simple thinking tests, have their brain activity recorded using EEG, and perform walking tasks that include stepping over obstacles.
Interventions
None listed
Sponsors
National Yang Ming Chiao Tung University
Study design
Observational model
CASE_ONLY
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* A clinical diagnosis of idiopathic Parkinson's disease; * Stable use of prescribed antiparkinsonian medication for at least two weeks; * Modified Hoehn and Yahr stage I to III; * Age between 18 and 80 years; * Ability to ambulate independently for at least 30 meters without assistive devices; * A Mini-Mental State Examination (MMSE) score of ≥ 24; * Corrected vision and hearing sufficient to effectively receive external stimuli
Exclusion criteria
* The presence of any neurological, musculoskeletal, or cardiovascular disorders that could affect participation in this study; * The presence of psychiatric disorders that could interfere with the ability to follow instructions or comply with study procedures; * A history of brain surgery, such as deep brain stimulation (DBS)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Event-related potential - N2 | 1 day | Measure event-related potential through electroencephalography during the Go/No-go test |
| Event-related potential - P300 | 1 day | Measure event-related potential through electroencephalography during the Go/No-go test |
| Stroop color and word test | 1 day | Record numbers of corrected color words which the subject responds within 45 sec |
| Step width | 1 day | Using the GAITRite system to measure step width |
| Stride length/Step length | 1 day | Using the GAITRite system to measure stride length and step length during obstacle crossing |
| Single support time | 1 day | Using the GAITRite system to measure single support time during obstacle crossing |
| Gait speed | 1 day | Gait speed during obstacle crossing was measured using the GAITRite system. Continuous obstacle-crossing walking performance was assessed using the GaitUp system. |
| Stride length | 1 day | Using the GaitUp system to measure stride length during continuous obstacle-crossing walking. |
| Swing phase | 1 day | Using the GaitUp system to measure swing phase during continuous obstacle-crossing walking. |
| Swing width | 1 day | Using the GaitUp system to measure swing width during continuous obstacle-crossing walking. |
| Four Square Step Test | 1 day | The Four Square Step Test is a test used to assess the ability to step over objects and measures the time in seconds to navigate all four squares. |
Countries
Taiwan
Contacts
CONTACTYea-Ru Yang, PhD
Outcome results
None listed