Hypoxemia During Surgery, Lung Cancer, OLV
Conditions
Keywords
EIT, OLV, Hypoxemia, lung cancer
Brief summary
Patients undergoing thoracic surgery with one-lung ventilation (OLV) are prone to hypoxemia, which is primarily attributable to pulmonary ventilation-perfusion (V/Q) mismatch. This study will preoperatively assess the distribution of pulmonary ventilation under spontaneous breathing and intraoperatively record the lowest peripheral oxygen saturation (SpO₂) during OLV. The aim is to investigate the correlation between these two parameters. The findings are expected to facilitate the prediction of hypoxemia in thoracic surgical patients undergoing OLV.
Interventions
None listed
Sponsors
Peking University People's Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age ≥ 18 years * BMI \> 18.5 and \< 30 * Informed consent obtained
Exclusion criteria
* • Inability to use the EIT belt preoperatively * Failure to implement one-lung ventilation during surgery
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Lowest SpO₂ during OLV | Perioperative | We will record the value of the lowest peripheral oxygen saturation (SpO₂) during intraoperative one-lung ventilation. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Postoperative functional status | Follow-up assessments with both questionnaires were conducted at 6 and 12 months postoperatively. | After hospital discharge, The Lung Cancer Symptom Scale (LCSS) questionnaires will be administered to patients via telephone by trained follow-up personnel. LCSS typically includes items that evaluate the intensity of symptoms such as cough, dyspnea, pain, fatigue, appetite loss, and insomnia, as well as the impact of these symptoms on daily activities. Each item is rated on a numerical scale, and the total score reflects the overall symptom burden, with higher scores indicating more severe symptoms. |
| postoperative quality of life | Follow-up assessments with both questionnaires were conducted at 6 and 12 months postoperatively. | After hospital discharge, The Cancer Therapy-Lung (FACT-L) questionnaire will be administered to patients via telephone by trained follow-up personnel. FACT-L is a widely used quality-of-life questionnaire that combines the general FACT-G (General) items with a lung-cancer-specific (LCS) module .Scores are calculated for each domain and a total score, with higher scores indicating better quality of life. |
Countries
China
Outcome results
None listed