Periodontitis, Smoking Cessation, Tobacco Dependence
Conditions
Keywords
periodontitis, nicotine gingival intoxication, periodontal outcomes, periodontitis non surgical treatment
Brief summary
Impact of nicotine gingival intoxication on the clinical outcomes after periodontitis non surgical treatment
Detailed description
In patients suffured of periodontitis, to evaluate the effect of nicotine gingival tissue intoxication and others smoking indicators on the severity of periodontitis and outcomes after nonsurgical periodontal treatment."
Interventions
PROCEDUREperiodontal non-surgical treatment
The procedure will consist of non-surgical periodontal treatment (NSPT), consisting of the removal of supra- and subgingival plaque using ultrasonic instruments. Prior to the NSPT, all unstimulated saliva will be collected using Eppendorf. During local anesthesia for the NSPT, a gingival tissue biopsy will be performed using a 2mm wide and 4mm deep punch in the maxillary retromolar area behind the last tooth in the arch.
Sponsors
University of Liege
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Outcomes Assessor)
Intervention model description
comparison between smokers and non-smokers
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
patient suffured of periodontitis, smoker and non-smoker * patient suffured of periodontitis * smoker and non-smoker * presence of a minimum of 6 teeth at each arch * minimum of 6 teeth with pocket depth of 5 mm * signed informed consent
Exclusion criteria
* diabetes, * connective tissue disease * pregnancy * radiotherapy * chemotherapy * psychological disease * previous periodontal therapy * antibiotics intake
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| nicotine/cotinine in gum (ng/ml) | the day of the periodontal non surgical treatment | concentration cotinine and nicotine (ng/ml) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| PD (mm) | baseline, the day of periodontal non- surgical treatment(PNST) , 3,6 and 12 months after PNSTs after | periodontal pocket depth (mm) Secondary outcomes: percentage of sites with PD ≥ 6 mm, furcation involvement, mobility assessment, bleeding on probing score (BoP), plaque score (PI). |
| % PD ≥ 6 mm (%) | baseline, the day of periodontal non- surgical treatment(PNST) , 3,6 and 12 months after PNSTs after | percentage of sites with PD ≥ 6 mm |
| FTND score ( 0 to 9) | the day of periodontal non-surgical treatment | Fagerström test for nictnie dependance ( scale from 0 to 9) 0-2: Very low dependence 3-4: Low dependence 5: Medium dependence 6-7: High dependence 8-10: Very high dependence |
| PY (number/year) | the day of periodontal non-surgical treatment | number of packet of cigarettes smoked per year |
| NCC (0 to 100) | the day of periodontal non-surgical treatment | number of cigartes consummed per day * PK: number of packet of cigarettes smoked per year * FTND: Fagerström test for nictnie dependance |
| Furc (I,II or III) | baseline, the day of periodontal non- surgical treatment(PNST) , 3,6 and 12 months after PNSTs after | furcation involvement |
| periodontal ouctomes | baseline, the day of periodontal non- surgical treatment(PNST) , 3,6 and 12 months after PNSTs after | tooth mobility ( 1,2 or 3) |
| BOP (%) | baseline, the day of periodontal non- surgical treatment(PNST) , 3,6 and 12 months after PNSTs after | bleeding on probing |
| PI (%) | baseline, the day of periodontal non- surgical treatment(PNST) , 3,6 and 12 months after PNSTs after | plaque score |
Countries
Belgium
Outcome results
None listed