Clinical Outcomes, Radiographic Outcomes, Lesion Sterilization, Tissue Repair, Zinc Oxide, 6-gingerol, Triple Antibiotic Paste, Non-vital, Primary Molars
Conditions
Brief summary
This study aims to evaluate and compare the clinical and radiographic outcomes of Lesion sterilization and tissue repair using zinc oxide/ 6-gingerol mix versus triple antibiotic paste in non-vital primary molars.
Detailed description
In routine dental practice, clinicians often face challenges when primary teeth are affected by dental caries and periapical changes, which may exceed the limits of conventional endodontic treatments. Extraction often becomes the only viable option due to factors like extensive root resorption, poor bone support, and uncooperative young patients. One promising less invasive method is Lesion Sterilization and Tissue Repair (LSTR), developed by Niigata University. This approach uses minimal instrumentation and applies an antibiotic mixture to disinfect the root canal and periapical lesions, often using a "three mix MP paste" of metronidazole, ciprofloxacin, and minocycline. Recently, clindamycin has been used instead of minocycline to avoid tooth discoloration.
Interventions
OTHERZinc oxide/ 6-gingerol mix
Lesion sterilization and tissue repair (LSTR) using zinc oxide/ 6-gingerol mix.
Lesion sterilization and tissue repair (LSTR) using triple antibiotic paste.
Sponsors
Al-Azhar University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
4 Years to 8 Years
Healthy volunteers
No
Inclusion criteria
* Age from 4 to 8 years. * Both sexes * Children must have at least two restorable non-vital primary molars * Periapical radiolucency. * Pain on mastication. * Pathological mobility. * Internal or external root resorption. * Furcation involvement should not extend to the developing tooth germ.
Exclusion criteria
* Presence of systemic diseases. * Teeth with physiological mobility near exfoliation time. * Teeth with vital pulp.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Assessment of pain | 6 months postoperatively | Pain will be assessed using age-appropriate pain scales (5-point Likert scale for children) with 0 typically representing "no pain" and 4 representing "very high/extreme pain". |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Tooth mobility | One year postoperatively | Tooth mobility is the horizontal or vertical looseness of a tooth beyond its normal physiological range. It is graded from 0 (no mobility) to 3 (severe, \>2mm or vertical movement). |
Countries
Egypt
Contacts
CONTACTAhmed E El-Metwally, MBBCH
Outcome results
None listed