Association Between Intraoperative Mean Arterial Pressure Variability and Postoperative Fatigue in Patients Undergoing Laparoscopic Abdominal Surgery

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07481006

Enrollment

366

Registered

2026-03-18

Start date

2026-04-15

Completion date

2026-06-30

Last updated

2026-07-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Blood Pressure Variability, Fatigue Symptom

Brief summary

This prospective cohort study aims to investigate the relationship between intraoperative mean arterial pressure (MAP) variability and postoperative fatigue syndrome (POFS) in elderly patients (≥18 years) undergoing laparoscopic abdominal surgery. The main research question is: Does the degree of intraoperative MAP fluctuation correlate with postoperative fatigue in elderly patients? Eligible patients scheduled for elective laparoscopic abdominal surgery under general anesthesia will have their intraoperative blood pressure variability recorded (generalized average real variability, G-ARV), and postoperative fatigue and recovery will be assessed on postoperative days 1, 3, and 7 using the Christensen fatigue scale.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

1. Age ≥ 18 years; 2. ASA physical status I-III; 3. Scheduled for elective laparoscopic abdominal surgery under general anesthesia.

Exclusion criteria

1. Severe cardiac, hepatic, or renal insufficiency, or major neurological or psychiatric disorders; 2. Known allergy to drugs used during the study; 3. Participation in other clinical trials within the past 3 months; 4. Unable to complete the required questionnaires or assessments; 5. Surgery duration \< 60 minutes.

Design outcomes

Primary

Measure	Time frame	Description
Postoperative Fatigue (Christensen Score)	Postoperative days 1, 3, and 7	Primary outcome is the patient's fatigue level measured using the Christensen fatigue scale on postoperative days 1, 3, and 7. This scale evaluates overall fatigue severity including physical exhaustion, muscle weakness, and attention deficits after laparoscopic abdominal surgery.

Secondary

Measure	Time frame	Description
Intraoperative Vasoactive Drug Use	During surgery	Total dose of vasoactive drugs administered during surgery
Postoperative Recovery Quality (QoR-15 Score)	Postoperative days 1, 3, and 7	Postoperative recovery quality is assessed using the Quality of Recovery-15 (QoR-15) questionnaire on postoperative days 1, 3, and 7. The QoR-15 consists of 15 items, each scored from 0 (worst recovery) to 10 (best recovery). The total score ranges from 0 to 150, with higher scores indicating better postoperative recovery. Recovery quality can be categorized as excellent (136-150), good (122-135), moderate (90-121), and poor (0-89).

Countries

China

Outcome results