Glycaemic Index Measurement of an Oral Nutritional Supplement With Biomarker Assessment and Lifestyle Monitoring in Healthy Participants

Status

Not yet recruiting

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07479251

Enrollment

Registered

2026-03-18

Start date

2026-03-01

Completion date

2026-12-01

Last updated

2026-03-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy Participants

Brief summary

This clinical trial evaluates the postprandial glycaemic response to an Oral Nutritional Supplement (ONS), a Food for Special Medical Purposes (FSMP), in healthy adults. The study uses a crossover design comparing the ONS to the reference product glucose. Each participant will consume both test and reference products on three separate occasions each, overall on six test days.

Interventions

DIETARY_SUPPLEMENTONS

Each administration of the test product (ONS) will represent 25 g of glycaemic carbohydrates.

OTHERglucose

The test product will be compared with the reference product glucose (glucose monohydrate dissolved in 250 ml water). Each administration of the reference product will represent 25 g of glycaemic carbohydrates.

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 60 Years

Healthy volunteers

Yes

Inclusion criteria

* Aged ≥18 and ≤60 years, adult healthy Caucasian or Chinese participants * Stable body weight within the Body Mass Index between 18.5 kg/m2 and 27.9 kg/m2 (inclusive) * Glycated hemoglobin \< 6%/\< 42 mmol/mol

Exclusion criteria

* Pregnant or lactating, * Body fat percentage exceeding 30%, * Known history of metabolic diseases or diabetes mellitus, * Major medical or surgical event requiring hospitalization within the preceding 3 months * Medical condition(s) or medication(s) or herbal effects known to affect glucose regulation, tolerance or appetite and/or which influence digestion and absorption of nutrients (excluding oral contraceptives), * Use of steroids, protease inhibitors, amphetamines or antipsychotics

Design outcomes

Primary

Measure	Time frame	Description
Glycaemic Index (GI) of ONS	Blood samples will be obtained at -5, 0, 15, 30, 45, 60, 90, and 120 minutes.	Three GIs for each repeated test of the ONS (based on capillary blood glucose) and their average GI (mean value) will be calculated as per ISO 26642.

Contacts

CONTACTSangeetha Thondre, Dr

pthondre@brookes.ac.uk+44 1865 534136

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 24, 2026