Impact of Aortic Diseases on Quality of Life and Work Ability

Impact of Aortic Disease on Patients' Quality of Life and Working Capacity

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07479186

Acronym

IMPACT-A

Enrollment

300

Registered

2026-03-18

Start date

2026-03-31

Completion date

2028-06-30

Last updated

2026-06-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aortic Diseases

Brief summary

Aortic diseases encompass a wide spectrum of congenital and acquired, acute and chronic conditions, characterized by high clinical and prognostic complexity. The aorta plays a central role in blood flow distribution and hemodynamic modulation owing to its elastic properties, which become progressively impaired with aging and in the presence of genetic or degenerative factors. Beyond clinical outcomes, aortic diseases lead to a marked reduction in health-related quality of life, psychological well-being, and functional capacity, with significant occupational and social consequences, thereby making multidisciplinary management necessary. This longitudinal observational study aims to systematically assess health-related quality of life, fatigue, psychological well-being, and work ability in patients with aortic diseases, with the objective of providing objective bases for occupational risk evaluation and promoting an interdisciplinary management model that integrates clinical, psychological, and work-related aspects, thereby supporting the maintenance or recovery of work functioning.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 70 Years

Healthy volunteers

Inclusion criteria

* Male and female patients with a confirmed diagnosis of aortic disease under the care of the Complex Operative Unit of Vascular Surgery of the Fondazione Policlinico Universitario Agostino Gemelli IRCCS. * Patients aged between 18 and 70 years.

Exclusion criteria

* Patients younger than 18 years or older than 70 years. * Incomplete diagnostic workup. * Patients who have undergone surgical procedures or experienced concomitant acute events unrelated to the aorta, with a predominant and recent functional impact, that make it impossible to isolate the effect of aortic disease on return to work.

Design outcomes

Primary

Measure	Time frame	Description
Change in Work Ability Index (WAI) score from baseline to 12 months in patients with aortic diseases	12 months	Work ability will be assessed using the Work Ability Index (WAI), a validated questionnaire composed of seven dimensions evaluating current work ability, work demands, health status, sickness absence, prognosis of future work ability, and psychological resources. The total WAI score ranges from 7 to 49 points, with higher scores indicating better work ability. The primary outcome is the change in total WAI score between baseline and the 12-month follow-up assessment.

Countries

Italy

Contacts

CONTACTIvo Iavicoli, Prof

ivo.iavicoli@unicatt.it+ 39 0630155145

PRINCIPAL_INVESTIGATORIvo Iavicoli, Prof

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Outcome results