Examine the Epidemiology and Outcomes of Transitions From PD-to-HD in Canada

Understand, Plan and Improve Care and Wellbeing of Patients at High Risk of Transfer From Peritoneal Dialysis to Hemodialysis, Epidemiology (Phase 1)

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07477210

Acronym

UPLIFT-PD CORR

Enrollment

17000

Registered

2026-03-17

Start date

2005-01-01

Completion date

2027-12-01

Last updated

2026-03-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hemodialysis, Kidney Replacement Therapy, Peritoneal Dialysis (PD)

Keywords

Transition, Transfer to hemodialysis

Brief summary

Transitions from peritoneal dialysis to hemodialysis are common during kidney replacement therapy and may be associated with adverse outcomes. However, the incidence, predictors, and outcomes of PD-to-HD transitions at a national level remain incompletely characterized. This study will use Canadian dialysis and hospitalization databases to examine the epidemiology and outcomes of PD-to-HD transitions among adults initiating dialysis in Canada. The study will evaluate transition incidence, predictors, and post-transition outcomes including mortality, transplantation, modality changes, and hospitalizations.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Adults (≥18 years) * Dialysis initiation in Canada between January 1, 2005 and December 31, 2018 * Peritoneal dialysis duration \>30 consecutive days

Exclusion criteria

* Dialysis initiation in Quebec or Manitoba during the study period * Dialysis initiation in a foreign country * Missing data on initial dialysis modality * Pre-emptive kidney transplantation

Design outcomes

Primary

Measure	Time frame	Description
Incidence of transfer from peritoneal dialysis to hemodialysis	From PD initiation until 1-year after PD start Also assessed at from PD initation until 2- and 5-year after PD start.	Measured as cumulative incidence and incidence rate of transitions following initiation of PD and censored at time of death, kidney transplantation, transfer home hemodialysis, or administrative end of follow-up.

Secondary

Measure	Time frame	Description
All-cause mortality after transfer from peritoneal dialysis to hemodialysis	From first day after transfer up to 1-year post transfert. Also assessed ad 2- and 5-year post transfer	Censored for kidney transplantation, transfer home hemodialysis, return to PD or administrative end of follow-up December 31st, 2018
Return to Peritoneal Dialysis	From first day after transfer to HD up to 180-day post transfer. Also measured at 90- and 365-day post transfer.	Defined as ≥1 consecutive day of peritoneal dialysis after transition and censored at time of death, kidney transplantation, transfer home hemodialysis or administrative end of follow-up December 31st, 2018)
Transfer to Home Hemodialysis	From first day after transfer to HD until 180-day post transfer. Also measured at 90- and 365-day post transfer	Defined as ≥30 consecutive days of home hemodialysis censored at time of death, kidney transplantation, return to PD or administrative end of follow-up December 31st, 2018)

Countries

Canada

Outcome results