Diabetic Nephropathy, Dyslipidemia
Conditions
Keywords
Chronic kidney disease ( CKD ), Diabetes mellitus type 1, Diabetes mellitus type 2
Brief summary
The study aims to examine the relationship between the non-high-density lipoprotein cholesterol-to-high-density lipoprotein cholesterol ratio (NHHR) and CKD in patients with DM.
Detailed description
The study will include adult participants recruited from outpatient clinics and inpatient departments. Participants will be classified into the following groups: 1. Diabetes Mellitus without Diabetic Nephropathy (DM group) : Patients with diabetes mellitus who have no evidence of diabetic nephropathy will be defined by a normal urinary albumin-to-creatinine ratio (UACR) and preserved renal function. 2. Diabetic Nephropathy group (DN group) : Patients with diabetes mellitus and diabetic nephropathy will be defined by the presence of elevated UACR and/or impaired renal function as assessed by estimated glomerular filtration rate (eGFR). Subgroup Analysis : Within the diabetic nephropathy group, further subgroup analyses will be performed to assess differences in NHHR according to: Type of diabetes (Type 1 vs. Type 2 diabetes mellitus) Stages of chronic kidney disease (CKD) are classified based on KDIGO definitions of CKD based on estimated GFR and albuminuria. Type of the study: Comparative cross-sectional study
Interventions
None listed
Sponsors
Assiut University
Study design
Observational model
OTHER
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Adults aged ≥18 years * Diagnosed cases of diabetes mellitus (Type 1 or Type 2), with or without diabetic nephropathy * Willingness to participate and provide informed consent
Exclusion criteria
* Known non-diabetic causes of chronic kidney disease * Acute kidney injury * Chronic inflammatory or autoimmune diseases * Current use of medications known to significantly alter lipid metabolism (other than standard lipid-lowering therapy, if applicable) * End-stage renal disease patients on dialysis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Association between the non-high-density lipoprotein cholesterol-to-high-density lipoprotein cholesterol ratio (NHHR) and the presence of diabetic nephropathy. | At baseline | Diabetic nephropathy defined as urinary albumin-to-creatinine ratio (UACR) ≥30 mg/g and/or estimated glomerular filtration rate (eGFR) \<60 mL/min/1.73 m², measured at enrollment. The non-HDL cholesterol to HDL cholesterol ratio (NHHR) will be calculated from fasting lipid profile obtained at the same visit. |
Contacts
CONTACTRagaey Edward Riad
PRINCIPAL_INVESTIGATORAhmed Mohamed Ashmawy, Professor
Assiut University
PRINCIPAL_INVESTIGATORNoha Gamal Abdel-Malek, Assistant lecturer
Assiut University
Outcome results
None listed