Chronic Knee Osteoarthritis
Conditions
Brief summary
The goal of this prospective randomized control trial is to provide continued pain relief, classically long-lasting 3 to12 months, and enhanced function in patients following: both gender; male and female, age group; \>50yr, healthy volunteers along with Radiographic diagnosis of knee OA with KL grade 3 and 4 in addition of Chronic knee pain ≥ 6 months and patients with ≥50% decrease in pain strength after diagnostic genicular nerve block. The main question it aims to answer is: Is ultrasound-guided genicular nerve RFA more efficient in lowering pain intensity at six months contrasted with fluoroscopic guided method in patients with chronic knee osteoarthritis? Researchers will compare Group A (Fluoroscopic) to Group B (Ultrasound) to see comparison in efficiency of ultrasound guided against fluoroscopic guided genicular nerves block for decrease in pain intensity and functional improvement.
Interventions
PROCEDUREUltrasound Guided
Genicular nerves radiofrequency ablation will be done with the help of ultrasound guidance.
PROCEDUREFluoroscope Guided
Control group in which genicular nerves radiofrequency ablation will be done with the help of fluoroscopic guidance.
Sponsors
Aga Khan University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
50 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Both gender patients of age more than 50 years. * Radiographic diagnosis of knee OA with KL level 3 and 4. * Chronic knee pain for more than 6 months * Patients with more than 50% reduction in pain intensity after diagnostic genicular nerve block
Exclusion criteria
* Lack of consent * surgery of knee * Patient with BMI more than 40kg/m2 * Intra-articular steroid injection or hyaluronic acid in last 3 months * Localized infection at procedure site or knee. * Patient unable to communicate properly (Severe psychiatric illness, severe dementia and cognitive impairment). * Patients have moderate to severe low back pain (NRS ≥5)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Effectiveness of Block | Post procedure 2 weeks, then follow up after 2, 4 and 6 months. | Block will be considered effective if decrease in pain score from baseline is \>50% at six months. And this will measure by using the 11-point Numeric Rating Scale (NRS) where 0 = no pain and 10 = worst imaginable pain. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Functional Improvement after block | 6 months | Functional improvement after genicular nerve block is describe as \> 20 % decrease in KOOS PS score from baseline at six months. Functional condition will be assessed using the Knee injury and osteoarthritis outcomes score-Physical function short form (KOOS-PS) tool. Minimum score is 0 and maximum is 20 which will then be converted into ratio from 0 to 100%, 0 means no functional impairment and 100 means maximum functional impairment. |
Contacts
CONTACTAli Sarfraz Siddiqui, MBBS-FCPS
PRINCIPAL_INVESTIGATORAli Sarfraz Siddiqui, MBBS-FCPS
Aga Khan University
Outcome results
None listed