Edentulism, Tooth Loss
Conditions
Keywords
biological drilling, low speed drilling, dental implants, implant stability, autogenous bone particals, BMP-2, VEGF, mandibular implants
Brief summary
This randomized clinical trial aims to evaluate the effect of different low-speed biological drilling protocols on implant stability and the osteogenic potential of autogenous bone particles collected during implant osteotomy. Patients requiring single dental implant placement in the mandible will be randomly assigned to different drilling speed protocols without irrigation. Implant stability will be measured clinically, while collected bone particles will be analyzed for osteogenic markers. The study aims to determine whether biological drilling improves implant stability and preserves the regenerative potential of autogenous bone.
Detailed description
Primary implant stability and the biological quality of bone particles generated during osteotomy are important determinants of successful osseointegration. Conventional implant site preparation typically uses high-speed drilling with irrigation to prevent thermal injury; however, this technique may compromise the biological quality and viability of harvested bone particles. Low-speed biological drilling without irrigation has been proposed as an alternative technique that may preserve bone vitality, reduce thermal trauma, and allow collection of viable autogenous bone particles with regenerative potential. This randomized clinical trial evaluates the influence of different mandibular drilling speeds (50 rpm, 150 rpm, and 300 rpm) during implant osteotomy on implant stability and on the osteogenic potential of the collected autogenous bone particles. Implant stability will be assessed clinically, while the osteogenic potential of harvested bone particles will be evaluated using molecular biomarkers related to osteogenesis. The results of this study may provide evidence-based guidance for optimizing implant drilling protocols and improving bone regeneration potential in implant dentistry.
Interventions
PROCEDUREImplant osteotomy using biological drilling at 50 rpm without irrigation.
Implant osteotomy will be performed using low-speed biological drilling at 50 rpm without irrigation. Bone particles produced during drilling will be collected for evaluation of osteogenic potential.
PROCEDUREImplant osteotomy using biological drilling at 150 rpm without irrigation.
Implant osteotomy will be performed using biological drilling at 150 rpm without irrigation. Autogenous bone particles generated during drilling will be collected and analyzed for osteogenic potential.
PROCEDUREImplant osteotomy using biological drilling at 300 rpm without irrigation.
Implant osteotomy will be performed using biological drilling at 300 rpm without irrigation with collection of autogenous bone particles for laboratory analysis.
Sponsors
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Masking description
The investigator responsible for laboratory analysis of bone particle samples and outcome assessment will be blinded to the drilling speed group allocation.
Intervention model description
Participants requiring a single mandibular dental implant will be randomly assigned to one of three drilling speed protocols during implant osteotomy. The drilling speeds include 50 rpm, 150 rpm, and 300 rpm without irrigation. Implant stability will be assessed after implant placement, and autogenous bone particles generated during osteotomy will be collected for laboratory evaluation of osteogenic potential.
Eligibility
Sex/Gender
ALL
Age
20 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
Adult patients requiring single dental implant placement in the mandible Adequate bone volume for implant placement without need for bone grafting Good general health Ability to provide informed consent
Exclusion criteria
Systemic diseases affecting bone metabolism or healing History of radiotherapy in the head and neck region Uncontrolled diabetes mellitus Active periodontal disease Heavy smoking Pregnancy or lactation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Implant Stability | At time of insertion and 3 months postoperatively. | Implant stability will be measured immediately after implant placement and 3 months postoperatively, using resonance frequency analysis (RFA). Implant stability will be recorded as an Implant Stability Quotient (ISQ) value to evaluate the mechanical stability of the implant in relation to the drilling speed used during osteotomy. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Osteogenic Potential of Autogenous Bone Particles | Immediately after bone particle collection and subsequent laboratory analysis. | Autogenous bone particles generated during implant osteotomy will be collected and analyzed for osteogenic biomarkers associated with bone formation and regeneration. Laboratory analysis will include molecular assessment of osteogenic markers using ELISA and PCR techniques. |
Outcome results
None listed