Labour Duration, Primigravida
Conditions
Keywords
Valethamate bromide, Hyoscine butyl bromide, Primigravida, Labour duration
Brief summary
Labour is a physiological process that enables the natural delivery of fetus, placenta and membranes after the age of viability. This study compared the efficacy of valethamate bromide and hyoscine butyl bromide in reducing labour duration among primigravid women at Alex Ekwueme Federal University Teaching Hospital, Abakaliki
Detailed description
Labour is a physiological process that enables the natural delivery of fetus, placenta and membranes after the age of viability. When labour is prolonged, it may defeat the whole essence of pregnancy as a result of poor outcome. Efforts have been made to prevent prolonged labour which includes the use of certain medications such as hyoscinebutyl bromide and valethamate bromide. However, there is paucity of studies comparing the effectiveness of both drugs, which could provide a better choice of reducing labour duration and its attendants' complications. AIM: This study compared the efficacy of valethamate bromide and hyoscine butyl bromide in reducing labour duration among primigravid women at Alex Ekwueme Federal University Teaching Hospital, Abakaliki. RESEARCH METHOD: This was a randomized controlled study where equal members of primigravid women at term were recruited and received 8 mg (2 ml) of valethamatebromide;20 mg (2 ml) of hyoscine butyl bromideand 2ml of sterile water. Either valethamate bromide 8mg, hyoscine butyl bromide20mg and no intervention (2 ml of sterile water) were given intravenously to the women who met the criteria. The data obtained were analyzed using statistical package for social science (SPSS) software (version 2022, Chicago II, USA). Categorical variables were presented as numbers and percentages while continuous variables were presented as mean and standard deviation (mean + 25D). Logistic regression was used where appropriate. A difference with a P value of ≤ 0.05 was taken to be statistically significant.
Interventions
DRUGValethamate Bromide
Two ml (16mg) of valethamate bromide was given intravenously to the patient who has attained active phase labour parameters
Two ml (40mg) of hyoscine butylbromide was given intravenously to the patient who has attained active phase labour parameters
OTHERSterile water
Two ml of water was given intravenously to the patient who has attained active phase labour parameters
Sponsors
Federal Teaching Hospital Abakaliki
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* Primigravidae / nulliparae. * Singleton term pregnancy with no evidence of maternal or fetal distress. * Women with fetus in cephalic presentation. * Age: 18- 35 years. * Women with no contra-indications to vaginal delivery. * Cervical dilatations of 4- 9cm when in labour * Spontaneous or induced labour. * Patients on epidural analgesia
Exclusion criteria
* Multiple gestations. * Women with abnormal fetal presentation. * Absolute indications for caesarean section. * Antepartum hemorrhage. * Evidence of maternal or fetal distress. * Fibroid in pregnancy. * Grand multiparous patients. * Previous uterine scar/ surgery or ruptures. * Medical disorders of pregnancy like pre-eclempsia, Eclempsia, Dm etc. * If any other antispasmodics agent had been used within the last 48 hours. * Preterm/ term premature rupture of membranes. * History of cervical injury/ surgery. * Hypersensitivity to valethamate bromide and/or hyoscine butyl bromide
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Rate of cervical dilatation | 8hours | This was the rate of dilation of the cervix per hour in patients in active phase of labour |
Countries
Nigeria
Contacts
PRINCIPAL_INVESTIGATORAssumpta N Nweke
Alex Ekwueme Federal University Teaching Hospital Abakaliki Ebonyi State
Outcome results
None listed