Hernia, Inguinal, Inguinal Hernia
Conditions
Keywords
Pneumoperitoneum, Laparoscopic Inguinal Hernia Repair, Serum Bicarbonate, Blood Gas Analysis, TAPP Technique
Brief summary
The goal of this observational study is to learn how the length of pneumoperitoneum during laparoscopic inguinal hernia surgery may affect changes in blood bicarbonate levels. Pneumoperitoneum is the use of carbon dioxide gas to create space inside the abdomen during laparoscopic surgery. The main question this study aims to answer is whether a longer pneumoperitoneum time is associated with changes in blood bicarbonate levels after surgery. Participants are adults undergoing laparoscopic inguinal hernia repair as part of their routine medical care. Researchers will measure blood gas values, including bicarbonate levels, before surgery and again two hours after surgery. The change in bicarbonate levels will be compared with the duration of pneumoperitoneum during the operation. The results of this study may help improve the understanding of metabolic changes that occur during laparoscopic surgery.
Detailed description
Carbon dioxide pneumoperitoneum is routinely used during laparoscopic surgery to provide adequate visualization and working space. However, absorption of carbon dioxide and increased intra-abdominal pressure may influence acid-base balance during the perioperative period. These physiological changes may be reflected in blood gas parameters such as pH, partial pressure of carbon dioxide (pCO2), and serum bicarbonate levels. This prospective observational study aims to evaluate the relationship between pneumoperitoneum duration and perioperative changes in serum bicarbonate levels in patients undergoing laparoscopic inguinal hernia repair using the transabdominal preperitoneal (TAPP) technique. Adult patients undergoing elective laparoscopic inguinal hernia repair will be included in the study. Blood gas measurements will be obtained before surgery and at the second postoperative hour. Serum bicarbonate levels will be recorded, and the difference between preoperative and postoperative measurements (ΔHCO3-) will be calculated. The primary outcome of the study is the change in serum bicarbonate levels between the preoperative and postoperative second-hour measurements. Secondary outcomes include postoperative pain scores, postoperative acid-base parameters such as pH and pCO2, and early postoperative complications within the first 24 hours. Pneumoperitoneum duration will be recorded intraoperatively and analyzed for its association with perioperative metabolic changes. The findings of this study may contribute to a better understanding of metabolic alterations occurring during laparoscopic surgery and their potential clinical implications.
Interventions
PROCEDURELaparoscopic Inguinal Hernia Repair (TAPP)
Standard laparoscopic inguinal hernia repair performed using the transabdominal preperitoneal (TAPP) technique as part of routine clinical care. Pneumoperitoneum duration during the procedure will be recorded for analysis.
Sponsors
Haseki Training and Research Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age ≥18 years * Patients undergoing laparoscopic inguinal hernia repair using the TAPP technique * Ability to provide informed consent
Exclusion criteria
* Pregnancy * Severe cardiovascular disease * Renal insufficiency * Patients requiring additional intra-abdominal surgical procedures * Strangulated inguinal hernia requiring bowel resection
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Serum Bicarbonate Level | Preoperative to postoperative 2 hours | Difference between preoperative and postoperative second-hour serum bicarbonate levels measured by blood gas analysis in patients undergoing laparoscopic inguinal hernia repair. Unit of Measure: mmol/L |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Postoperative Pain Score | Within 24 hours after surgery | Postoperative pain intensity measured using the Visual Analog Scale (VAS). The scale ranges from 0 to 10, where 0 indicates no pain and 10 indicates the worst imaginable pain. Higher scores represent greater pain severity. Unit of Measure: VAS score (0-10) |
| Change in Arterial Blood pH | Preoperative to postoperative 2 hours | Change in arterial blood pH measured during pneumoperitoneum. Unit of Measure: pH |
| Early Postoperative Complications | Within 24 hours | Early postoperative complications occurring within the first 24 hours after laparoscopic inguinal hernia repair. |
| Change in Arterial Partial Pressure of Carbon Dioxide | Preoperative to postoperative 2 hours | Change in arterial PaCO₂ levels measured intraoperatively. Unit of Measure: mmHg |
Countries
Turkey (Türkiye)
Contacts
CONTACTOsman Sibic, MD
CONTACTBahar Canbay Torun, MD
PRINCIPAL_INVESTIGATORMuzaffer Akinci, MD
Haseki Training and Research Hospital
Outcome results
None listed