Cirrhosis, Portal Hypertension, Noncirrhotic, Portal Hypertension Related to Cirrhosis, Portal Vein Thrombosis
Conditions
Brief summary
This is a retrospective-prospective study conducted at Zhongshan Hospital, Fudan University, to explore portal vein thrombosis (PVT) in patients with cirrhosis and gastroesophageal varices (GEV). It aimed to provide insights into the diagnosis, follow-up, and factors influencing PVT recanalization, to help patients, families, and healthcare providers understand the disease and related clinical management.
Interventions
None listed
Sponsors
Shanghai Zhongshan Hospital
Study design
Observational model
COHORT
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Inclusion criteria
* diagnosed as cirrhosis and confirmed gastroesophageal varices by endoscopy; * all patients were diagnosed as PVT by CTA at admission.
Exclusion criteria
* patients with hepatocellular carcinoma; * patients with extrahepatic malignancies; * history of liver transplantation or TIPS; * lack of information regarding anticoagulation therapy； * those with cavernous transformation of the portal vein(CTPV) .
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PVT recanalization at 1 year | From the first abdominal imaging assessment after admission, until the occurrence of PVT recanalization at 1 year, death, or the last follow-up, whichever came first |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Occurrence of all-cause death (competing event) | From the date of admission confirmation of PVT to the occurrence of death, or the last follow-up, whichever came first | — |
| PVT recanalization at 5 years | From the first abdominal imaging assessment after admission, until the occurrence of PVT recanalization at 5 year, death, or the last follow-up, whichever came first | — |
| Occurrence of non-improved PVT | From the date of admission confirmation of PVT to the last radiological follow-up at 1 year, or death, whichever came first | defined as unchanged thrombus size, \<50% thrombus reduction, or thrombus extension to new venous segments |
Countries
China
Contacts
CONTACTSiyu Jiang, Dr.
Outcome results
None listed