Abdominal Aortic Aneurysm
Conditions
Keywords
Imaging for Aneurysm Abdominal, Imaging for Abdominal Aneurysms
Brief summary
A first-in-human evaluation of \[64Cu\]-RYM2 with PET/CT will be performed to: a) assess its safety, biodistribution, and radiation dosimetry in normal volunteers (WU) and; b) in AAA patients undergoing surgery (WU and Yale), evaluate radiotracer pharmacodynamics and correlate PET imaging characteristics (WU) with ex vivo tissue measurements (Yale).
Detailed description
A first-in-human evaluation of \[64Cu\]-RYM2 with PET/CT will be performed to: a) assess its safety, biodistribution, and radiation dosimetry in normal volunteers (WU) and; b) in AAA patients undergoing surgery (WU and Yale), evaluate radiotracer pharmacodynamics and correlate PET imaging characteristics (WU) with ex vivo tissue measurements (Yale).
Interventions
DRUGCu-64-RYM2
PET/CT scan
DRUGPET imaging using Cu-64
PET/CT at different timepoints
Sponsors
Washington University School of Medicine
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
Healthy Volunteers * No history of claustrophobia or other preventing condition that has previously or would interfere with completion of protocol-specified imaging sessions. * Able to comprehend and willing to follow instructions for the study procedures as called for by the protocol. * Capable of lying still and supine within the PET/CT scanner for \~1 hour and follow instructions for breathing protocol during the CT portion. * No illicit drug use or other inhaled drug use (including pharmacologic agents, recreational agents, or illicit drugs) within the past year. * No known history of cardiac, pulmonary, hepatic or renal disease or diabetes * BMI ≤ 40
Exclusion criteria
Healthy Volunteers * Inability to receive and sign informed consent; * Pregnant (confirmed by urine pregnancy test) and/or breastfeeding * Patient with chronic renal disease whose glomerular filtration rate (GFR) is less than 30 mL/min/1.73 m2 * Patients with an unstable clinical condition that in the opinion of the principal investigators or designee precludes participation in the study. * Is deemed likely to be unable to perform all research procedures for any reason, (e.g., subjects unable to lie still or inability to tolerate up to 60 minutes in a supine position with arms up during the PET imaging procedures due to chronic back/shoulder pain or arthritis as assessed by physical examination and medical history). * Currently using recreational drugs. * Body weight of \>300 lbs. (weight limit of the PET table). * Currently enrolled in another study using an investigational drug or underwent a study the last year involving investigational use of radiotracers or CT would confound results or with a radiation exposure when combined with this study would be deemed as excessive by the Sponsor-Investigator. Inclusion Criteria: Patients with AAA electively or semi-electively scheduled for surgical repair * Men or women 40-80 years of age * Willing and able to provide informed consent * Medically managed hypertension and hyperlipidemia * No history of claustrophobia or other preventing condition that has previously or would interfere with completion of protocol-specified imaging sessions * Able to comprehend and willing to follow instructions for the study procedures as called for by the protocol * Patients with AAA indicated for surgical repair (5.0 \[female\] - 5.5cm \[male\]), incidentally identified large(r) AAAs (\>5.5 or 6.0 cm), and rapidly expanding AAAs (\> 0.5 cm in 6 months or \> 1 cm in 12 months) per Guidelines of the Society for Vascular Surgery.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Verification Cu-64RYM2-2 signal in AAA segments. This will be performed by measuring Standard Uptake Values obtained from analysis of the Cu-64RYM2 images, in AAA patients. | 2 years | Verification Cu-64RYM-2 signal is present in AAA segment of the abdominal aorta |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Cu-64RYM-2 signal is higher | 2 years | MMP activity will be higher in AAA patients than in healthy volunteers |
Countries
United States
Contacts
CONTACTKitty Harrison, RN, BSN
CONTACTRobert Gropler, MD
PRINCIPAL_INVESTIGATORRobert Gropler, MD
Washington University School of Medicine
Outcome results
None listed